Dubikaĭtis A Iu, Belotserkovskiĭ M V, Koniukhova S G, Strashnov V I
Biull Eksp Biol Med. 1993 Feb;115(2):148-51.
The composition of blood was evaluated (parameters of blood clinical analysis, figures of lipid peroxidation processes and system of antioxidant protection, traditional biochemical blood parameters, total proteolytic activity and peptides of blood plasma, quantity and activity of some parameters of humoral immunity) in patients with late stages of peripheral atherosclerosis. It was showed that chronic endotoxicosis appeared in these patients. The processes of chronic endotoxicosis are compensated in patients with the 3-d stage of low extremities ischemia. The quantity of endogenic toxins and markers of endogenic intoxication increased in patients with the 4-th stage of ischemia and loading on the system of detoxication was enlarged; and as a result, compensation reserves of detoxication system of organism decreased.
对晚期外周动脉粥样硬化患者的血液成分进行了评估（血液临床分析参数、脂质过氧化过程和抗氧化保护系统指标、传统血液生化参数、血浆总蛋白水解活性和肽类、体液免疫某些参数的数量和活性）。结果表明，这些患者出现了慢性内毒素血症。在下肢缺血3期患者中，慢性内毒素血症过程得到代偿。在缺血4期患者中，内源性毒素数量和内源性中毒标志物增加，解毒系统负担加重；结果，机体解毒系统的代偿储备下降。
