Liu Dong, Zhou Huadong, Tao Yong, Tan Jun, Chen Lin, Huang Haiyang, Chen Yang, Li Yafei, Zhou Rui
Department of Orthopedics, the Orthopedic Surgery Center of Chinese PLA, Southwest Hospital, Third Military Medical University, Chongqing, 400038, P.R. China.
Curr Alzheimer Res. 2016;13(10):1165-72. doi: 10.2174/15672050113109990149.
The aim of this study was to analyze the relationship between Alzheimer's disease (AD) and a risk of osteoporosis in the elderly cohort of Chongqing, China.
A prospective study with 6 years of follow-up in 1802 patients aged 60- 75 was conducted from January 2007 to June 2013. Dual energy X-ray absorptiometry was utilized to evaluate bone mineral density (BMD). Their cognitive function was detected using the Chinese version of the Mini-Mental State Examination (MMSE) and a detection of the instrumental activities of daily living (ADL). Cox proportional hazards models were used to detect the association between AD and the risk of osteoporosis.
After adjusting for age, female, AD, 25-hydroxyvitamine D (25(OH)D), smoking, drinking and stroke, AD (Hazard ratio, HR 2.48, 95%CI 1.66-2.94), age (HR 1.36, 95% CI 1.14-1.60), female (HR 1.39, 95% CI 1.17-1.65), 25(OH)D (HR1.34, 95%CI 1.11-1.59), current smoking (HR 1.27, 95%CI 1.22-1.43), daily drinking (HR 1.33, 95%CI 1.11-1.52) and stroke (HR 1.26, 95%CI 1.14-1.58) were associated with increased risk of osteoporosis. In osteoporosis fracture group, osteoporosis with AD was more common than osteoporosis with normal cognition function.
AD was associated with an increased risk of osteoporosis in the elderly cohort of Chongqing, China.
本研究旨在分析中国重庆老年人群中阿尔茨海默病（AD）与骨质疏松症风险之间的关系。
2007年1月至2013年6月，对1802名年龄在60 - 75岁的患者进行了为期6年的前瞻性研究。采用双能X线吸收法评估骨密度（BMD）。使用中文版简易精神状态检查表（MMSE）检测其认知功能，并检测日常生活活动能力（ADL）。采用Cox比例风险模型检测AD与骨质疏松症风险之间的关联。
在调整年龄、女性、AD、25-羟基维生素D（25(OH)D）、吸烟、饮酒和中风因素后，AD（风险比，HR 2.48，95%置信区间1.66 - 2.94）、年龄（HR 1.36，95%置信区间1.14 - 1.60）、女性（HR 1.39，95%置信区间1.17 - 1.65）、25(OH)D（HR 1.34，95%置信区间1.11 - 1.59）、当前吸烟（HR 1.27，95%置信区间1.22 - 1.43）、每日饮酒（HR 1.33，95%置信区间1.11 - 1.52）和中风（HR 1.26，95%置信区间从1.14 - 1.58）均与骨质疏松症风险增加相关。在骨质疏松性骨折组中，伴有AD的骨质疏松症比认知功能正常的骨质疏松症更为常见。
在中国重庆老年人群中，AD与骨质疏松症风险增加相关。
