Department of Cardiovascular Surgery, Daping Hospital, Third Military Medical University, Chongqing, China.
Am J Cardiol. 2012 Oct 15;110(8):1138-42. doi: 10.1016/j.amjcard.2012.05.053. Epub 2012 Jul 3.
Cardiovascular disease (CVD) and osteoporosis share some common risk factors such as old age, smoking, alcoholic drinking, hypertension, diabetes mellitus, and hyperlipidemia. Although previous studies have investigated the association of bone mineral density (BMD) with CVD, the results were conflicting. There are limited studies on the association of BMD loss rate with CVD. We therefore conducted a 5-year prospective study to examine the relation among BMD, bone loss, and risk of CVD in a Chinese cohort. Of 9,657 community residents 30 to 75 years old, 6,092 were enrolled in the study and followed annually for 5 years. At baseline demographic data, BMD, smoking and drinking statuses, medical history, and blood samples were collected. Cox proportional hazards analysis was used to evaluate the association of BMD and incidence of CVD. Over the 5-year follow-up period, CVD developed in 118 subjects. Baseline BMD, bone loss rate, current smoking, daily alcoholic ingestion, and higher osteoprotegerin and leptin levels were independently associated with increased risk of CVD, whereas higher baseline adiponectin level was associated with decreased risk of CVD in women and men. In conclusion, uncovering the relation linking osteoporosis and CVD is important for understanding the pathogenesis of these 2 common disorders.
心血管疾病（CVD）和骨质疏松症有一些共同的危险因素，如年龄、吸烟、饮酒、高血压、糖尿病和高脂血症。虽然之前的研究已经探讨了骨密度（BMD）与 CVD 的相关性，但结果存在争议。关于 BMD 丢失率与 CVD 的相关性的研究有限。因此，我们进行了一项为期 5 年的前瞻性研究，以检查中国队列中 BMD、骨质流失与 CVD 风险之间的关系。在 30 至 75 岁的 9657 名社区居民中，有 6092 人入组并在 5 年内每年进行随访。基线时收集人口统计学数据、BMD、吸烟和饮酒状况、病史和血液样本。使用 Cox 比例风险分析评估 BMD 与 CVD 发生率的关系。在 5 年的随访期间，118 名受试者发生 CVD。基线 BMD、骨丢失率、当前吸烟、每日饮酒量以及较高的护骨素和瘦素水平与 CVD 风险增加独立相关，而较高的基线脂联素水平与女性和男性 CVD 风险降低相关。总之，揭示骨质疏松症和 CVD 之间的关系对于理解这两种常见疾病的发病机制非常重要。
