XRCC1 基因遗传多态性与中国汉族人群胃癌易感性的关系。
Genetic polymorphisms of XRCC1 gene and susceptibility to gastric cancer in Chinese Han population.
机构信息
Department of General Surgery, Changhai Hospital, The Second Military Medical University , Shanghai , People's Republic of China.
出版信息
Biomarkers. 2013 Sep;18(6):542-6. doi: 10.3109/1354750X.2013.822562. Epub 2013 Aug 6.
This study aims to evaluate whether the c.1471G > A and c.1686C > G genetic polymorphisms of XRCC1 gene influencing gastric cancer susceptibility. A total of 813 subjects with Chinese Han ethnicity were enrolled. Our data suggest that the allele and genotype frequencies are significantly different from gastric cancer patients with cancer-free controls. We find that c.1471G > A and c.1686C > G genetic polymorphisms statistically increase the risk of gastric cancer. Our findings indicate these two genetic polymorphisms are related with the susceptibility to gastric cancer, and could be used as molecular markers for detecting gastric cancer in Chinese Han ethnicity.
本研究旨在评估 XRCC1 基因的 c.1471G > A 和 c.1686C > G 遗传多态性是否影响胃癌易感性。共纳入 813 名汉族个体。我们的数据表明，等位基因和基因型频率与无癌对照组的胃癌患者有显著差异。我们发现 c.1471G > A 和 c.1686C > G 遗传多态性显著增加了胃癌的发病风险。我们的研究结果表明，这两种遗传多态性与胃癌易感性相关，可作为汉族人群胃癌检测的分子标志物。
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