Division of Pediatric Endocrinology/Diabetes, Louisiana State University-Health Sciences Center and Children's Hospital, New Orleans, LA.
J Pediatr. 2013 Nov;163(5):1427-31. doi: 10.1016/j.jpeds.2013.06.044. Epub 2013 Aug 3.
To estimate skin content of advanced glycation endproducts (AGEs) by measurements of skin intrinsic fluorescence (SIF) from youth with diabetes in comparison with a population of youth and adults without diabetes.
Using a specialized instrument, skin AGEs were estimated from skin auto-fluorescence induced at 420 nm and corrected for skin pigmentation (SIF420[kx0.5, km0.5]) in children with types 1 and 2 diabetes, as well as children and adults without diabetes. The effect of age, sex, ethnicity, and diabetes status on SIF420[kx0.5, km0.5] was analyzed.
SIF420[kx0.5, km0.5] increased with chronologic age and was higher in children with diabetes compared with children without diabetes (P = .0001). SIF420[kx0.5, km0.5] from 43% of children with type 1 diabetes and 55% with type 2 diabetes overlapped the range of adults without diabetes. SIF420[kx0.5, km0.5] was higher in girls than boys in patients with diabetes patients. However, there was no effect of sex or race on SIF420[kx0.5, km0.5] in subjects without diabetes.
After 4-6 years' exposure to diabetes, many children will have precociously high estimates of skin AGEs, comparable with levels that would naturally accumulate only after ∼25 years of chronologic aging. Potentially, this technology identifies children who are at increased risk for complications.
通过比较有和无糖尿病的青年人群，利用皮肤固有荧光（SIF）测量，评估糖尿病青年的皮肤晚期糖基化终产物（AGEs）含量。
使用专门的仪器，通过在 420nm 处诱导皮肤自体荧光并校正皮肤色素（SIF420[kx0.5, km0.5]），评估 1 型和 2 型糖尿病患儿以及无糖尿病的儿童和成人的皮肤 AGEs。分析年龄、性别、种族和糖尿病状态对 SIF420[kx0.5, km0.5]的影响。
SIF420[kx0.5, km0.5]随年龄增长而增加，且糖尿病患儿高于无糖尿病患儿（P=0.0001）。1 型糖尿病患儿中 43%和 2 型糖尿病患儿中 55%的 SIF420[kx0.5, km0.5]与无糖尿病成人的范围重叠。糖尿病患儿中，女孩的 SIF420[kx0.5, km0.5]高于男孩。然而，无糖尿病受试者中，性别或种族对 SIF420[kx0.5, km0.5]无影响。
暴露于糖尿病 4-6 年后，许多儿童的皮肤 AGEs 会过早升高，与自然积累 25 年左右的年龄老化相比，水平相当高。这项技术可能会识别出有并发症风险增加的儿童。
