Adami C, Wenker C, Hoby S, Morath U, Bergadano A
Department of Veterinary Clinical Science, Anaesthesiology and Pain Therapy Division, Vetsuisse Faculty, University of Berne, Switzerland.
Schweiz Arch Tierheilkd. 2013 Aug;155(8):471-6. doi: 10.1024/0036-7281/a000493.
In 8 captive adult chimpanzees of various ages premedicated with oral zuclopenthixol anaesthesia was induced intramuscularly with a combination of medetomidine and ketamine (40 or 50 µg/kg and 5 mg/kg, IM, respectively), with and without midazolam (0.05 mg/kg), and maintained with isoflurane in oxygen. At the end of the procedure, sedation was reversed with atipamezole (0.25 mg/kg, IM) and sarmazenil (0.005 mg/kg, IM) when midazolam had been administered. Oral zuclopenthixol resulted in tranquillization of the whole group and only one animal required a second dart injection to achieve adequately deep anaesthesia. Effective and reliable anaesthesia was achieved in all apes; the depth of hypnosis was stable and sudden arousal did not occur. Physiological parameters remained within normal ranges in the majority of the animals; however, manageable anaesthesia-related complications, namely apnoea after darting, hypotension, hypoventilation, hypoxemia and prolonged recovery, occurred in 6 out of 8 animals. The use of monitoring devices was essential to guarantee adequate management of these complications.
在8只成年圈养黑猩猩中，它们年龄各异，预先口服珠氯噻醇进行预处理，然后分别肌肉注射美托咪定和氯胺酮（分别为40或50 μg/kg和5 mg/kg）诱导麻醉，其中部分使用了咪达唑仑（0.05 mg/kg），部分未使用，麻醉维持采用异氟烷和氧气。手术结束时，若使用了咪达唑仑，则用阿替美唑（0.25 mg/kg，肌肉注射）和沙马西尼（0.005 mg/kg，肌肉注射）逆转镇静状态。口服珠氯噻醇使整个群体安静下来，只有一只动物需要第二次注射麻醉镖才能达到足够深的麻醉状态。所有猿类均实现了有效且可靠的麻醉；催眠深度稳定，未出现突然觉醒的情况。大多数动物的生理参数保持在正常范围内；然而，8只动物中有6只出现了可处理的麻醉相关并发症，即注射麻醉镖后呼吸暂停、低血压、通气不足、低氧血症和恢复时间延长。使用监测设备对于确保对这些并发症进行充分管理至关重要。
