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用于测量成像引导程序中患者照射量的光激励发光剂量计。

An optically stimulated luminescence dosimeter for measuring patient exposure from imaging guidance procedures.

机构信息

Department of Radiation Oncology, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, B-902, TVC, 1301 Medical Center Drive, Nashville, TN 37232-5671, USA.

出版信息

Phys Med Biol. 2013 Sep 7;58(17):5885-97. doi: 10.1088/0031-9155/58/17/5885. Epub 2013 Aug 6.

Abstract

There is a growing interest in patient exposure resulting from an x-ray imaging procedure used in image-guided radiation therapy. This study explores a feasibility to use a commercially available optically stimulated luminescence (OSL) dosimeter, nanoDot, for estimating imaging radiation exposure to patients. The kilovoltage x-ray sources used for kV-cone-beam CT (CBCT) imaging acquisition procedures were from a Varian on-board imager (OBI) image system. An ionization chamber was used to determine the energy response of nanoDot dosimeters. The chamber calibration factors for x-ray beam quality specified by half-value layer were obtained from an Accredited Dosimetry Calibration Laboratory. The Monte Carlo calculated dose distributions were used to validate the dose distributions measured by using the nanoDot dosimeters in phantom and in vivo. The range of the energy correction factors for the nanoDot as a function of photon energy and bow-tie filters was found to be 0.88-1.13 for different kVp and bow-tie filters. Measurement uncertainties of nanoDot were approximately 2-4% after applying the energy correction factors. The tests of nanoDot placed on a RANDO phantom and on patient's skin showed consistent results. The nanoDot is suitable dosimeter for in vivo dosimetry due to its small size and manageable energy dependence. The dosimeter placed on a patient's skin has potential to serve as an experimental method to monitor and to estimate patient exposure resulting from a kilovoltage x-ray imaging procedure. Due to its large variation in energy response, nanoDot is not suitable to measure radiation doses resulting from mixed beams of megavoltage therapeutic and kilovoltage imaging radiations.

摘要

人们对影像引导放射治疗中使用的 X 射线成像程序所导致的患者受照剂量越来越感兴趣。本研究探索了使用市售的光激励发光(OSL)剂量计(nanoDot)来估算患者成像辐射暴露的可行性。千伏锥形束 CT(CBCT)成像采集过程中使用的千伏 X 射线源来自瓦里安的机载成像仪(OBI)影像系统。采用电离室来确定 nanoDot 剂量计的能量响应。射线束质的半值层规定的剂量计校准因子由经过认可的剂量校准实验室获得。蒙特卡罗计算的剂量分布用于验证在体模和体内使用 nanoDot 剂量计测量的剂量分布。发现 nanoDot 的能量修正因子的范围随光子能量和蝴蝶结滤线器的变化而在 0.88-1.13 之间,对于不同的 kVp 和蝴蝶结滤线器。应用能量修正因子后,nanoDot 的测量不确定度约为 2-4%。将 nanoDot 放置在 RANDO 体模和患者皮肤上的测试结果一致。nanoDot 由于其尺寸小且能量依赖性可管理,因此适合用于体内剂量测量。放置在患者皮肤上的剂量计有可能作为一种实验方法,用于监测和估算由千伏 X 射线成像程序引起的患者受照剂量。由于能量响应的变化很大,nanoDot 不适合测量兆伏治疗射线和千伏成像射线混合束产生的辐射剂量。

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