唾液支原体将氨的产生作为一种毒力表现形式。

Ammonia production as a virulence expression by Mycoplasma salivarium.

作者信息

Matsuura M, Seto K, Watanabe T

机构信息

Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Kanagawa.

出版信息

Microbiol Immunol. 1990;34(5):467-70. doi: 10.1111/j.1348-0421.1990.tb01029.x.

DOI:10.1111/j.1348-0421.1990.tb01029.x

PMID:2392067

Abstract

Rabbits were inoculated intracutaneously with M. salivarium (ATCC 23064) cells. The size of the resulting swelling was significantly larger in 1) the sites inoculated with viable cells (7.5 x 10(9) CFU) suspended in a medium with arginine (arginine medium) than in those inoculated with killed cells, and in 2) those inoculated with cells suspended in arginine medium than with cells suspended in arginine-free medium. The swelling was enhanced when rabbits had previously been immunized with the organism. This effect was concluded to be due to ammonia which the organism produced by the hydrolysis of arginine through the arginine-dihydrolase pathway.

摘要

将唾液分枝杆菌（ATCC 23064）细胞皮内接种于兔子。在以下两种情况下，所产生肿胀的大小明显更大：1）接种于悬浮在含精氨酸培养基（精氨酸培养基）中的活细胞（7.5×10⁹CFU）的部位，大于接种死细胞的部位；2）接种于悬浮在精氨酸培养基中的细胞的部位，大于接种于无精氨酸培养基中细胞的部位。当兔子先前用该生物体免疫时，肿胀会增强。得出该效应是由于该生物体通过精氨酸二水解酶途径水解精氨酸产生的氨所致。