Department of Pharmaceutics, UCL School of Pharmacy, London, UK.
Skin Pharmacol Physiol. 2013;26(4-6):277-85. doi: 10.1159/000351934. Epub 2013 Jul 29.
This paper addresses the application of physical chemistry towards understanding the processes of percutaneous penetration. Over the years, this approach has been used by the subject of this review to advance our knowledge of the skin and to interpret, model and predict dermal delivery. The basic laws of diffusion provide a framework for the comprehension of skin permeability and, as a corollary, how the barrier function can be modulated. The importance of understanding the physicochemical properties of potential skin permeants is highlighted. Rational formulation strategies for passive skin delivery are outlined. However, the overriding emphasis is that multidisciplinary approaches must be used to advance the field. This is exemplified in the work and references cited.
本文探讨了物理化学在理解经皮渗透过程中的应用。多年来，本综述的主题一直采用这种方法来增进我们对皮肤的了解，并解释、建模和预测经皮给药。扩散的基本定律为理解皮肤通透性提供了一个框架，因此也可以解释屏障功能如何被调节。强调了理解潜在经皮渗透物的物理化学性质的重要性。概述了用于被动经皮给药的合理制剂策略。然而，必须采用多学科方法来推动该领域的发展，这是本文的重点。引用的工作就证明了这一点。
