Janneck M, Velden J, Iking-Konert C
Zentrum für Innere Medizin, III. Medizinische Klinik und Poliklinik, Klinik für Nephrologie und Rheumatologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.
Z Rheumatol. 2013 Aug;72(6):555-68; quiz 569-70. doi: 10.1007/s00393-013-1182-1.
Renal involvement and renal function disorders are commonplace in patients with rheumatic diseases and are often decisive for the prognosis. Typical nephrological complications in rheumatology are renal manifestations or delayed sequelae of the underlying disease in addition to drug-induced renal failure, e.g. by nonsteroidal anti-inflammatory drugs (NSAIDs). The differentiation from other common causes of disturbed renal function (e.g. diabetes and hypertension) is important and often difficult in individual cases. Renal involvement can be clinically manifested in many different ways. The spectrum ranges from slight functional disorders with, for example discrete erythrocyturia/proteinuria and normal renal function up to rapidly progressive renal failure. The probability of renal damage also varies greatly between different underlying diseases. For example, renal involvement in rheumatoid arthritis is a rarity but in contrast relatively normal in systemic lupus erythematosus. In the course of the differential diagnostics urine sediment, protein values and sonography are still the most important factors and the indications for kidney biopsy should be generously applied. Early initiation of immunosuppression can substantially improve the renal prognosis of inflammatory systemic diseases.
肾脏受累及肾功能障碍在风湿病患者中很常见,且往往对预后起决定性作用。除药物性肾衰竭(如非甾体抗炎药所致)外,风湿病典型的肾脏并发症是潜在疾病的肾脏表现或延迟后遗症。在个体病例中,将其与其他常见的肾功能障碍原因(如糖尿病和高血压)相鉴别很重要,但往往也很困难。肾脏受累可有多种不同的临床表现。范围从轻微的功能障碍,例如轻度红细胞尿/蛋白尿且肾功能正常,到快速进展的肾衰竭。不同潜在疾病之间肾脏损害的可能性也有很大差异。例如,类风湿关节炎患者肾脏受累较为罕见,但相比之下,系统性红斑狼疮患者的肾脏受累情况相对常见。在鉴别诊断过程中,尿沉渣、蛋白值和超声检查仍然是最重要的因素,应广泛应用肾脏活检指征。早期开始免疫抑制可显著改善炎症性全身性疾病的肾脏预后。