Department of Orthopedics, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, PR China.
PLoS One. 2013 Jul 26;8(7):e69052. doi: 10.1371/journal.pone.0069052. Print 2013.
To compare the variation patterns of ADC and T2 values in different age and intervertebral disc (IVD) levels, thus to identify their sensitivities in assessing age and disc level related IVDs changes.
The T2 and ADC values were recorded from 345 IVDs of 69 volunteers. Kendall's correlation analysis was used to identify the relationship between age and T2/ADC mean values respectively. The one-way analysis of variance (ANOVA) with post hoc analysis was then applied to test the differences of T2 and ADC values among different IVD levels and age groups, followed by linear regression analysis between age (<45 and >45 years) and T2/ADC mean values. This study was approved by the Ethics Committee of the Chinese Academy of Medical Sciences and the Peking Union Medical College Hospital.
Significant negative correlation was observed between age and T2/ADC mean values. The T2 and ADC values showed significant differences among IVD levels and among age groups except for T2 values in age group 1 (25-34 years) and group 2 (35-44 years), and for ADC values at L1-2 level. Both T2 and ADC values showed significant differences between young (age<45 years) and elderly group (age>45 years) at each IVD level. A linear relationship was observed between age and T2/ADC mean values in the elderly group as well as in the young group for the ADC mean values, while no such tendency was identified in the young group for the T2 mean values.
ADC values may be a more sensitive parameter than T2 in assessing age and disc level related intervertebral disc changes.
比较不同年龄和椎间盘（IVD）水平的 ADC 值和 T2 值的变化模式，从而确定它们在评估年龄和椎间盘水平相关的 IVD 变化中的敏感性。
从 69 名志愿者的 345 个椎间盘记录 T2 和 ADC 值。Kendall 相关分析用于分别确定年龄与 T2/ADC 平均值之间的关系。然后应用单向方差分析（ANOVA）和事后分析来测试不同 IVD 水平和年龄组之间的 T2 和 ADC 值的差异，然后进行年龄（<45 岁和>45 岁）与 T2/ADC 平均值之间的线性回归分析。本研究得到中国医学科学院和北京协和医学院医院伦理委员会的批准。
年龄与 T2/ADC 平均值之间存在显著负相关。除了年龄组 1（25-34 岁）和组 2（35-44 岁）的 T2 值以及 L1-2 水平的 ADC 值外，IVD 水平和年龄组之间的 T2 和 ADC 值均存在显著差异。在每个 IVD 水平上，年轻组（年龄<45 岁）和老年组（年龄>45 岁）之间的 T2 和 ADC 值均存在显著差异。在老年组和年轻组中，ADC 平均值与年龄之间存在线性关系，但在年轻组中，T2 平均值与年龄之间没有这种趋势。
在评估年龄和椎间盘水平相关的椎间盘变化方面，ADC 值可能比 T2 值更敏感。
