TMPRSS4 和 Erk1 的表达与中国胃癌患者的转移和预后不良相关。
The expression of TMPRSS4 and Erk1 correlates with metastasis and poor prognosis in Chinese patients with gastric cancer.
机构信息
Department of Radiology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, People's Republic of China.
出版信息
PLoS One. 2013 Jul 29;8(7):e70311. doi: 10.1371/journal.pone.0070311. Print 2013.
PURPOSE
The present study investigated the clinical significance of transmembrane protease, serine 4(TMPRSS4) and extracellular signal-regulated kinases 1 (Erk1) in the development, progression and metastasis of gastric cancer.
METHODS
Immunohistochemistry was employed to analyze TMPRSS4 and Erk1 expression in 436 gastric cancer cases and 92 non-cancerous human gastric tissues.
RESULTS
Protein levels of TMPRSS4 and Erk1 were up-regulated in gastric cancer lesions compared with adjacent noncancerous tissues. High expression of TMPRSS4 correlated with age, size, Lauren's classification, depth of invasion, lymph node and distant metastases, regional lymph node stage and TNM stage, and also with expression of Erk1. In stages I, II and III, the 5-year survival rate of patients with high TMPRSS4 expression was significantly lower than in patients with low expression. Further multivariate analysis suggests that up-regulation of TMPRSS4 and Erk1 were independent prognostic indicators for the disease, along with depth of invasion, lymph node and distant metastasis and TNM stage.
CONCLUSIONS
Expression of TMPRSS4 in gastric cancer is significantly associated with lymph node and distant metastasis, high Erk1 expression, and poor prognosis. TMPRSS4 and Erk1 proteins could be useful markers to predict tumor progression and prognosis of gastric cancer.
目的
本研究旨在探讨跨膜蛋白酶丝氨酸 4（TMPRSS4）和细胞外信号调节激酶 1（Erk1）在胃癌发生、发展和转移中的临床意义。
方法
采用免疫组织化学法检测 436 例胃癌组织和 92 例非癌性人胃组织中 TMPRSS4 和 Erk1 的表达。
结果
与相邻非癌组织相比，胃癌病变中 TMPRSS4 和 Erk1 蛋白水平上调。TMPRSS4 高表达与患者年龄、肿瘤大小、Lauren 分型、浸润深度、淋巴结和远处转移、区域淋巴结分期和 TNM 分期以及 Erk1 的表达有关。在Ⅰ、Ⅱ和Ⅲ期，TMPRSS4 高表达患者的 5 年生存率明显低于低表达患者。进一步的多因素分析表明，TMPRSS4 和 Erk1 的上调与浸润深度、淋巴结和远处转移以及 TNM 分期是疾病的独立预后指标。
结论
TMPRSS4 在胃癌中的表达与淋巴结和远处转移、高 Erk1 表达及不良预后显著相关。TMPRSS4 和 Erk1 蛋白可作为预测胃癌肿瘤进展和预后的有用标志物。
Zotero 插件