肝细胞癌中的精子蛋白17、MAGE-C1和NY-ESO-1：表达频率及其与临床参数的相关性
Sperm protein 17, MAGE-C1 and NY-ESO-1 in hepatocellular carcinoma: expression frequency and their correlation with clinical parameters.
作者信息
Xia Qiu-Yuan, Liu Song, Li Fang-Qiu, Huang Wen-Bin, Shi Li-Ning, Zhou Xiao-Jun
机构信息
Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210002, China.
出版信息
Int J Clin Exp Pathol. 2013 Jul 15;6(8):1610-6. Print 2013.
UNLABELLED
This study is dedicated to investigate the expression patterns of sperm protein 17 (Sp17), melanoma-specific antigen (MAGE)-C1 and New York esophageal squamous cell carcinoma-1 (NY-ESO-1), to explore the correlation between these cancer-testis antigens and clinical parameters, and to evaluate their values in diagnosis and differentiation of hepatocellular carcinoma.
METHODS
Immunohistochemical staining was performed in 45 paraffin-embedded hepatocellular carcinoma specimens. 45 normal peripheral hepatic tissues collected from adjacent non-cancerous areas were used as controls.
RESULTS
Positive results of immunohistostaining were obtained in 16 (35.6%), 7 (15.6%) and 36 (80.0%) samples using MAGE-C1, NY-ESO-1 and Sp17 antibodies, respectively. The immunoreactivity of Sp17 was also found in 7 (14.0%) control samples. A statistical correlation between the frequency of Sp17 expression and tumor differentiation grade in hepatocellular carcinoma was confirmed.
CONCLUSIONS
Sp17 is highly expressed in hepatocellular carcinoma cells. The frequency of Sp17 expression is closely related to the pathologic differentiation in hepatocellular carcinoma.
未标记
本研究致力于调查精子蛋白17（Sp17）、黑色素瘤特异性抗原（MAGE）-C1和纽约食管鳞状细胞癌-1（NY-ESO-1）的表达模式，探讨这些癌-睾丸抗原与临床参数之间的相关性，并评估它们在肝细胞癌诊断和鉴别诊断中的价值。
方法
对45例石蜡包埋的肝细胞癌标本进行免疫组织化学染色。从相邻非癌区域收集的45例正常外周肝组织用作对照。
结果
使用MAGE-C1、NY-ESO-1和Sp17抗体分别在16例（35.6%）、7例（15.6%）和36例（80.0%）样本中获得免疫组织化学染色阳性结果。在7例（14.0%）对照样本中也发现了Sp17的免疫反应性。证实了肝细胞癌中Sp17表达频率与肿瘤分化程度之间存在统计学相关性。
结论
Sp17在肝癌细胞中高表达。Sp17的表达频率与肝细胞癌的病理分化密切相关。
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