Farazi Paraskevi A, DePinho Ronald A
Department of Genetics, Division of Medical Sciences, Harvard University, Boston, Massachusetts 02115, USA.
Nat Rev Cancer. 2006 Sep;6(9):674-87. doi: 10.1038/nrc1934.
Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human population. Despite its significance, there is only an elemental understanding of the molecular, cellular and environmental mechanisms that drive disease pathogenesis, and there are only limited therapeutic options, many with negligible clinical benefit. This Review summarizes the current state of knowledge of this, the most common and dreaded liver neoplasm, and highlights the principal challenges and scientific opportunities that are relevant to controlling this accelerating global health crisis.
肝细胞癌是人类最致命且最常见的癌症之一。尽管其意义重大，但对于驱动疾病发病机制的分子、细胞和环境机制，人们仅有初步的了解，且治疗选择有限，其中许多的临床获益微乎其微。本综述总结了关于这种最常见且可怕的肝脏肿瘤的当前知识状态，并强调了与控制这一加速演变的全球健康危机相关的主要挑战和科学机遇。
