Qiao Jianjun, Sun Chang-E, Zhu Weifang, Zhu Dingxian, Fang Hong
Department of Dermatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Int J Clin Exp Pathol. 2013 Jul 15;6(8):1683-7. Print 2013.
Eosinophilic dermatosis of hematologic malignancy is a multifaceted dermatosis with a wide morphological spectrum, presenting as pruritic, erythematous, papular and occasionally vesicular, urticarial, nodular eruptions. Histopathologically eosinophil infiltration in the super and deep dermis was found. We reported a case of eosinophilic dermatosis of hematologic malignancy presented as urticarial and vesicular lesions in a patient with chronic lymphocytic leukemia. A skin biopsy revealed a prominent subepidermal blister and a diffuse infiltrate of eosinophils with flame figures in the dermis and subcutaneous tissue. Although flame figures associated with eosinophilic dermatosis of hematologic malignancy is rarely reported, we believe that it would not seem unusual to find them in this skin disease. Eosinophilic cellulitis, which share clinical and histological features with eosinophilic dermatosis of hematologic malignancy, has also been described as showing an association with hematoproliferative diseases. In order to clearly describe eosinophilic dermatosis in patients with hematologic malignancies, the terminology eosinophilic dermatosis of hematologic malignancy, instead of eosinophilic cellulitis, would be a more suitable term in patients with eosinophilic dermatosis.
血液系统恶性肿瘤相关嗜酸性粒细胞性皮肤病是一种具有广泛形态学谱的多方面皮肤病，表现为瘙痒性、红斑性、丘疹性，偶尔为水疱性、荨麻疹性、结节性皮疹。组织病理学检查发现真皮浅层和深层有嗜酸性粒细胞浸润。我们报告了1例血液系统恶性肿瘤相关嗜酸性粒细胞性皮肤病，表现为1例慢性淋巴细胞白血病患者的荨麻疹性和水疱性皮损。皮肤活检显示表皮下有明显水疱，真皮和皮下组织有嗜酸性粒细胞弥漫浸润及火焰状图形。虽然与血液系统恶性肿瘤相关嗜酸性粒细胞性皮肤病相关的火焰状图形很少被报道，但我们认为在这种皮肤病中发现它们似乎并不罕见。嗜酸性粒细胞性蜂窝织炎与血液系统恶性肿瘤相关嗜酸性粒细胞性皮肤病具有相同的临床和组织学特征，也被描述为与血液增殖性疾病有关。为了更清楚地描述血液系统恶性肿瘤患者的嗜酸性粒细胞性皮肤病，对于嗜酸性粒细胞性皮肤病患者，血液系统恶性肿瘤相关嗜酸性粒细胞性皮肤病这一术语比嗜酸性粒细胞性蜂窝织炎更合适。
