Schimmer B M, Bloch K J
J Rheumatol. 1975 Jun;2(2):241-50.
A case of mixed IgM-IgG cryoglobulinemia and polyarteritis nodosa is described. The patient exhibited non-deforming arthritis, Raynaud's phenomena, cutaneous vasculitis, and a sensory neuropathy.. The terminal phase of the illness was characterized by hypertension and retroperitoneal hemorrhage, with widespread large vessel arteritis. The isolated cryoprecipitate contained IgM, IgG, and C3 and possessed rheumatoid factor activity. Mild reduction in serum complement (CH50 and C3) was noted on one occasion. The evidence that these cryoprecipitable proteins may be acting as immune complexes and contributing to the arterial lesions is reviewed.
本文描述了一例混合性IgM-IgG冷球蛋白血症合并结节性多动脉炎的病例。患者表现为非变形性关节炎、雷诺现象、皮肤血管炎和感觉神经病变。疾病终末期的特征为高血压和腹膜后出血，并伴有广泛的大血管动脉炎。分离出的冷沉淀物含有IgM、IgG和C3，并具有类风湿因子活性。有一次发现血清补体（CH50和C3）轻度降低。本文对这些可冷沉淀蛋白可能作为免疫复合物并导致动脉病变的证据进行了综述。
