Katelaris C H, Walls R S
Ann Allergy. 1984 Sep;53(3):257-61.
It has been claimed that immunotherapy in allergic diseases may result in morbidity from chronic antigenic stimulation by the formation of immune complexes and by contributing to development of arteritis, amyloidosis and paraproteinaemia. We examined 35 older patients who received injections of allergen extracts for between two and 30 years and compared them with an age-matched control group. Treated patients had significantly higher serum IgG and lower total IgE than controls but no increased incidence of paraproteins or evidence of immune complex disease such as urinary abnormalities, increased Clq binding levels, cryoglobulins or rheumatoid fever.
有人声称，过敏性疾病的免疫疗法可能会因免疫复合物的形成以及导致动脉炎、淀粉样变性和副蛋白血症的发展而引发慢性抗原刺激导致的发病。我们检查了35名接受变应原提取物注射两至30年的老年患者，并将他们与年龄匹配的对照组进行比较。治疗组患者的血清IgG显著高于对照组，总IgE低于对照组，但副蛋白的发生率没有增加，也没有免疫复合物疾病的证据，如尿液异常、Clq结合水平升高、冷球蛋白或类风湿热。
