Edwards M L, Bambury R E, Ritter H W
J Med Chem. 1975 Jun;18(6):637-9. doi: 10.1021/jm00240a027.
The methylnitrone of 3-methyl-1,4-dioxidoquinoxaline-2-carboxaldehyde (1) has been exceptional antibacterial activity in vivo. Derivatives of 3-hydroxymethyl-1,4-dioxidoquinoxaline-2-carboxaldehyde and 3-acetoxymethyl-1,4-dioxidoquinoxaline-2-carboxaldehyde were prepared. Several of these compounds were found to be antibacterial agents of the same order of activity as I.
3-甲基-1,4-二氧代喹喔啉-2-甲醛（1）的甲基硝酮在体内具有卓越的抗菌活性。制备了3-羟甲基-1,4-二氧代喹喔啉-2-甲醛和3-乙酰氧基甲基-1,4-二氧代喹喔啉-2-甲醛的衍生物。发现其中几种化合物是与化合物I活性相当的抗菌剂。
