Kim H K, Miller L F, Bambury R E, Ritter H W
J Med Chem. 1977 Apr;20(4):557-60. doi: 10.1021/jm00214a019.
A series of alpha-quinoxalinyl-N-substitute nitrone 1,4-dioxides has been synthesize and evaluated as antibacterial and antiprotozoal agents. Structure-activity relationships are discussed. Of the compounds tested, alpha-(3-methyl-2-quinoxalinyl)-N-methylnitrone 1,4-dioxide (2) was the most active agent in vivo against the gram-negative and the gram-positive organisms.
