Khosrowbeygi A, Ahmadvand H
School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Bangladesh Med Res Counc Bull. 2013 Apr;39(1):18-21. doi: 10.3329/bmrcb.v39i1.15805.
The aim of the present study was to assess leptin/adiponectin ratio in preeclamptic patients compared with normal pregnant women. A cross-sectional study was designed. The study population consisted of 30 preeclamptic patients and 30 healthy pregnant women. Serum levels of total leptin and adiponectin were assessed using commercially available enzyme-linked immunosorbent assay methods. The one-way ANOVA and Student's t tests and Pearson's correlation analysis were used for statistical calculations. Levels of leptin and adiponectin were also adjusted for BMI. A p-value < 0.05 was considered statistically significant. The leptin/adiponectin ratio was increased significantly in preeclamptic patients. The leptin/adiponectin ratio was significantly higher in severe preeclamptic patient than in mild preeclampsia. Adjusted leptin/adiponectin ratio was also significantly increased in preeclamptic patients than in normal pregnant women. The findings of the present study suggest that the leptin/adiponectin ratio was increased in preeclamsia and imbalance between the adipocytokines could be involved in the pathogenesis of preeclampsia.
本研究的目的是评估子痫前期患者与正常孕妇的瘦素/脂联素比值。设计了一项横断面研究。研究人群包括30例子痫前期患者和30名健康孕妇。使用市售的酶联免疫吸附测定方法评估血清总瘦素和脂联素水平。采用单因素方差分析、Student's t检验和Pearson相关分析进行统计计算。瘦素和脂联素水平也根据体重指数进行了调整。p值<0.05被认为具有统计学意义。子痫前期患者的瘦素/脂联素比值显著升高。重度子痫前期患者的瘦素/脂联素比值明显高于轻度子痫前期患者。子痫前期患者经调整后的瘦素/脂联素比值也显著高于正常孕妇。本研究结果表明，子痫前期患者的瘦素/脂联素比值升高，脂肪细胞因子之间的失衡可能参与了子痫前期的发病机制。
