Halawi A, Abbas O, Mahalingam M
Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
J Eur Acad Dermatol Venereol. 2014 Apr;28(4):405-14. doi: 10.1111/jdv.12237. Epub 2013 Aug 7.
The structurally related, low-molecular weight S100 proteins constitute a family of proteins that possess a common basic structure allowing them to carry out a range of intracellular and extracellular functions. Unifying intracellular functions relate to regulation of proliferation, energy metabolism, calcium homeostasis, enzyme activities, cell growth and differentiation. Extracellular tasks, however, appear somewhat specific to select S100 members and include participation in innate and adaptive immune responses, tissue development and repair, and/or cell migration and chemotaxis. This review is an attempt to comprehensively summarize the function and expression of S100 proteins selectively expressed in normal skin and/or involved in diseased skin.
结构相关的低分子量S100蛋白构成了一个蛋白质家族，它们具有共同的基本结构，使其能够执行一系列细胞内和细胞外功能。统一的细胞内功能与增殖调节、能量代谢、钙稳态、酶活性、细胞生长和分化有关。然而，细胞外任务似乎对某些特定的S100成员具有特异性，包括参与先天性和适应性免疫反应、组织发育和修复，以及/或者细胞迁移和趋化作用。本综述旨在全面总结在正常皮肤中选择性表达和/或参与皮肤病的S100蛋白的功能和表达情况。
