Center of Supramolecular Organic and Organometallic Chemistry, Cluj-Napoca, Babeş-Bolyai University, 11 Arany Janos str., 400028, Cluj-Napoca, România.
J Org Chem. 2013 Sep 6;78(17):8722-9. doi: 10.1021/jo401432y. Epub 2013 Aug 20.
Various cryptands based on 1,3-dioxane decorated 1,3,5-trisubstituted-benzene building blocks, connected by different chains (exhibiting ester, ether, or triazol groups) to several units with C3 symmetry, are reported. The structure of the compounds was investigated by single crystal X-ray diffraction, NMR, and MS. The role of the 1,3-dioxane units was targeted to ensure the preorganization of the substrate for the macrocyclization reactions on one side, and for easier NMR assignment of the structure of the cryptands on the other side.
本文报道了几种基于 1,3-二氧杂环己烷修饰的 1,3,5-三取代苯砌块，通过不同的链（酯、醚或三唑基团）连接到几个具有 C3 对称性的单元上的多环穴醚。通过单晶 X 射线衍射、NMR 和 MS 研究了化合物的结构。1,3-二氧杂环己烷单元的作用一方面是为大环化反应的底物预组织，另一方面是为了更容易进行穴醚结构的 NMR 归属。
