新型糖类氮杂冠醚穴状配体的合成
Synthesis of new saccharide azacrown cryptands.
作者信息
Pintal Michalina, Charbonniere-Dumarcay Florence, Marsura Alain, Porwański Stanisław
机构信息
Department of Organic and Applied Chemistry, University of Łódź, Tamka 12, 91-403 Łódź, Poland.
SRSMC, Nancy Universite & CNRS, Faculte des Sciences et Techniques, B. 70239, F-54506 Vandoeuvre-les-Nancy Cedex, France.
出版信息
Carbohydr Res. 2015 Sep 23;414:51-9. doi: 10.1016/j.carres.2015.07.007. Epub 2015 Jul 23.
New cryptands including bis-azacrown and saccharidic moieties in their structure were prepared in several steps by applying Staudinger-aza-Wittig reaction (SAW). Syntheses have been started from cheap, easily available commercial compounds such as D-glucose, D-cellobiose and D-lactose subsequently transformed into their derivatives in fairly good yields (60-65%) and suitable to give desired final cryptands by direct SAW coupling reactions.
通过施陶丁格-氮杂-维蒂希反应（SAW）分几步制备了结构中包含双氮杂冠醚和糖类部分的新型穴状配体。合成从廉价、易于获得的商业化合物如D-葡萄糖、D-纤维二糖和D-乳糖开始，随后以相当高的产率（60-65%）转化为它们的衍生物，并且适合通过直接的SAW偶联反应得到所需的最终穴状配体。
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