*Department of Pediatric Oncology, Medical Faculty, Ondokuz Mayis University, Samsun 55039, Turkey.
Jpn J Clin Oncol. 2013 Oct;43(10):1004-11. doi: 10.1093/jjco/hyt105. Epub 2013 Aug 7.
Wilms' tumor, or nephroblastoma, is the most common primary malignant renal tumor of childhood. The excellent outcome now expected for most children with this tumor is attributed to the combination of effective adjuvant chemotherapy, improved surgical and anesthetic techniques and also the radiosensitivity of the tumor. The numerous organ systems are subject to the late effects of anticancer therapy. The aim of this study was to investigate the blood pressure profile and ambulatory blood pressure monitoring, and also cardiac diastolic functions and pulmonary venous flow in 25 children with unilateral Wilms' tumor in remission.
The patient group consists of 25 patients who successfully completed anticancer treatment for unilateral Wilms' tumor. Thirty-three age-, weight- and height-matched healthy children were considered as a control group for an echocardiographic study. Also, 20 age-, weight- and height-matched healthy children were considered as a control group for the ambulatory blood pressure monitoring study.
In our study, 24 h, daytime and night-time systolic blood pressure and night-time diastolic blood pressure measurements were found to be significantly increased in the patient group compared with healthy children. We detected diastolic filling pattern abnormalities. We also found increase in pulmonary venous flow (systolic and diastolic) in Wilms' tumor group.
We suggest the regular follow-up of survivors of Wilms' tumor for care and prevention of cardiovascular diseases.
肾母细胞瘤，又称 Wilms 瘤，是儿童最常见的原发性肾脏恶性肿瘤。目前，大多数患有这种肿瘤的儿童都能取得良好的预后，这归因于有效的辅助化疗、手术和麻醉技术的改进，以及肿瘤对放疗的敏感性。儿童的许多器官系统都会受到抗癌治疗的晚期影响。本研究旨在调查 25 例单侧 Wilms 瘤缓解期儿童的血压谱、动态血压监测以及心脏舒张功能和肺静脉血流。
患者组由 25 例成功完成单侧 Wilms 瘤抗癌治疗的患者组成。33 名年龄、体重和身高匹配的健康儿童被视为超声心动图研究的对照组。另外，20 名年龄、体重和身高匹配的健康儿童被视为动态血压监测研究的对照组。
与健康儿童相比，我们的研究发现患者组的 24 小时、白天和夜间收缩压和夜间舒张压测量值显著升高。我们还发现舒张期充盈模式异常，并发现 Wilms 瘤组肺静脉血流（收缩期和舒张期）增加。
我们建议对 Wilms 瘤幸存者进行定期随访，以进行心血管疾病的护理和预防。
