Atar Yavuz, Topaloglu Ilhan, Ozcan Deniz
Department of Otorhinolaryngology, Yenikent Government Hospital, Sakarya, Turkey.
Indian J Pathol Microbiol. 2013 Jan-Mar;56(1):40-2. doi: 10.4103/0377-4929.116147.
Metastatic renal cell carcinoma of the nasopharynx, nasal cavity, and paranasal sinuses can be misdiagnosed as primary malignant or benign diseases. A 33-year-old male attended our outpatient clinic complaining of difficulty breathing through the nose, bloody nasal discharge, postnasal drop, snoring, and discharge of phlegm. Endoscopic nasopharyngeal examination showed a vascularized nasopharyngeal mass. Under general anesthesia, multiple punch biopsies were taken from the nasopharynx. Pathologically, the tumor cells had clear cytoplasm and were arranged in a trabecular pattern lined by a layer of endothelial cells. After the initial pathological examination, the pathologist requested more information about the patient's clinical status. A careful history revealed that the patient had undergone left a nephrectomy for a kidney mass diagnosed as renal cell carcinoma 3 years earlier. Subsequently, nasopharyngeal metastatic renal cell carcinoma was diagnosed by immunohistochemical staining with CD10 and vimentin. Radiotherapy was recommended for treatment.
鼻咽、鼻腔和鼻窦的转移性肾细胞癌可能被误诊为原发性恶性或良性疾病。一名33岁男性到我们门诊就诊，主诉鼻塞、鼻出血、鼻后滴漏、打鼾和咳痰。鼻内镜检查显示鼻咽部有一个血管丰富的肿物。在全身麻醉下，从鼻咽部取了多次咬取活检组织。病理检查显示，肿瘤细胞胞质清晰，呈小梁状排列，内衬一层内皮细胞。初次病理检查后，病理学家要求了解更多患者的临床情况。详细询问病史发现，该患者3年前因肾脏肿物行左肾切除术，该肿物被诊断为肾细胞癌。随后，通过CD10和波形蛋白免疫组化染色诊断为鼻咽转移性肾细胞癌。建议进行放射治疗。
