Serra A, Caltabiano R, Giorlandino A, Musumeci A, Conti A, Zanghì G, Maniaci A, Cocuzza S
ENT Department of University of Catania, Italy.
Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Italy.
Pathologica. 2017 Dec;109(4):421-425.
Renal cell carcinoma is one of the most common tumours to spread by extranodal metastases to the head and neck. Metastatic renal cell carcinoma to the head and neck area has been demonstrated mostly in the paranasal sinuses, parotid gland, the mandible, larynx and hypopharinx. Renal cell carcinoma should be excluded whenever a metastatic lesion is encountered in the head and neck area, even if the metastatic lesion is the first clinical presentation. The diagnosis of metastatic RCC should be suspected in any patient with even a remote history of renal cell carcinoma. We report a case of 79 year old woman with recurrent episodes of rhinorrhea, headache, hyposmia and monolateral right epistaxis, with a history of RCC. We describe RCC nasal metastases in a metachronous bilateral neoplasm, in which a second occult lesion debuted with a homolateral nasal metastases, ten years after left nephrectomy.
肾细胞癌是最常见的通过结外转移扩散至头颈部的肿瘤之一。头颈部区域的转移性肾细胞癌大多见于鼻窦、腮腺、下颌骨、喉和下咽。无论何时在头颈部区域发现转移性病变，即使该转移性病变是首次临床表现，都应排除肾细胞癌。对于任何有肾细胞癌病史的患者，即使病史久远，都应怀疑转移性肾细胞癌的诊断。我们报告一例79岁女性患者，有鼻漏、头痛、嗅觉减退和右侧单侧鼻出血反复发作史，并曾患肾细胞癌。我们描述了一例异时性双侧肿瘤中的肾细胞癌鼻转移病例，该患者在左肾切除术后十年，第二个隐匿性病变以同侧鼻转移首次出现。
