Stability of Zidovudine and Dobutamine Hydrochloride Injections in 0.9% Sodium Chloride and 5% Dextrose Injections Stored at Ambient Temperature (23 +/- 2 Deg C) and 4 Deg C in 50-mL Polyvinyl Chloride Bags Up to 24 Hours.

The stability of a 2-mg/mL zidovudine and 1-mg/mL dobutamine hydrochloride admixture stored in 0.9% sodium chloride and 5% dextrose injections in 50-mL polyvinyl chloride bags at ambient temperature (23 +/- 2 deg C) and 4 deg C for up to 24 hours was studied. The samples were analyzed at 0, 4, 8, and 24 hours after preparation of the controls and known mixtures by means of a reverse-phase stability indicating high-performance liquid chromatographic method. The drug mixtures were stable for up to 24 hours, as shown by the greater than 90% of initial concentrations at the time of preparation. The pH of the drug solutions remained constant in the pH 6 to 7 range. These data support the stability of the zidovudine and dobutamine admixture under the storage conditions studied.