Musami Patrick, Stewart James T, Taylor E Will
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia.
Int J Pharm Compd. 2004 May-Jun;8(3):236-9.
The stability of a 2-mg/mL zidovudine and 0.5-mg/mL ranitidine admixture stored in 0.9% sodium chloride and 5% dextrose injections in 50-mL polyvinylchloride bags at ambient temperature and 4 deg C up to 24 hours was studied. The samples were analyzed at 0, 4, 8 and 24 hours after preparation of the controls and admixtures by means of a reverse-phase, stability-indicating, high-performance liquid chromatographic method. The drug mixtures were stable for up to 24 hours, showing levels of greater than 90% of the initial drug concentrations at the time of preparation. The pH of the admixtures was in the pH 5-6 range. These data support the stability of the zidovudine and ranitidine admixture under the storage conditions studied.
研究了2毫克/毫升齐多夫定与0.5毫克/毫升雷尼替丁在50毫升聚氯乙烯袋中于0.9%氯化钠注射液和5%葡萄糖注射液中混合，在环境温度和4℃下储存长达24小时的稳定性。通过反相、稳定性指示高效液相色谱法，在制备对照品和混合液后0、4、8和24小时对样品进行分析。药物混合物在长达24小时内稳定，在制备时显示出高于初始药物浓度90%的水平。混合液的pH值在5 - 6范围内。这些数据支持齐多夫定和雷尼替丁混合液在所研究储存条件下的稳定性。
