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CD40 therapy and surgery: a potential immunologic partnership.

作者信息

Byrne Katelyn T, Vonderheide Robert H

机构信息

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

J Immunother. 2013 Sep;36(7):359-61. doi: 10.1097/CJI.0b013e31829fb871.

DOI:10.1097/CJI.0b013e31829fb871
PMID:23924786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3795345/
Abstract
摘要

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CD40 therapy and surgery: a potential immunologic partnership.CD40疗法与手术：一种潜在的免疫协作关系。
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Locally administered TLR7 agonists drive systemic antitumor immune responses that are enhanced by anti-CD40 immunotherapy.局部给予的TLR7激动剂可驱动全身抗肿瘤免疫反应，抗CD40免疫疗法可增强这种反应。
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Blood. 2006 Apr 1;107(7):2786-9. doi: 10.1182/blood-2004-01-0113. Epub 2005 Dec 15.
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本文引用的文献

1
Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors.CD40激动剂抗体CP-870,893联合卡铂和紫杉醇治疗晚期实体瘤患者的I期研究。
Oncoimmunology. 2013 Jan 1;2(1):e23033. doi: 10.4161/onci.23033.
2
Agonistic CD40 antibodies and cancer therapy.激动性 CD40 抗体与癌症疗法。
Clin Cancer Res. 2013 Mar 1;19(5):1035-43. doi: 10.1158/1078-0432.CCR-12-2064.
3
Immunogenic potential of irradiated lymphoma cells is enhanced by adjuvant immunotherapy and modulation of local macrophage populations.辐照后的淋巴瘤细胞的免疫原性通过佐剂免疫治疗和局部巨噬细胞群体的调节得到增强。
Leuk Lymphoma. 2013 Sep;54(9):2008-15. doi: 10.3109/10428194.2013.769219. Epub 2013 Feb 18.
4
Cancer immunoediting by the innate immune system in the absence of adaptive immunity.先天免疫系统在缺乏适应性免疫的情况下对癌症进行免疫编辑。
J Exp Med. 2012 Sep 24;209(10):1869-82. doi: 10.1084/jem.20112738. Epub 2012 Aug 27.
5
T-cell-independent antitumor effects of CD40 ligation.CD40 配体的 T 细胞非依赖性抗肿瘤作用。
Int Rev Immunol. 2012 Aug;31(4):267-78. doi: 10.3109/08830185.2012.698337.
6
The use of agonistic anti-CD40 therapy in treatments for cancer.激动型抗 CD40 疗法在癌症治疗中的应用。
Int Rev Immunol. 2012 Aug;31(4):246-66. doi: 10.3109/08830185.2012.698338.
7
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.抗 PD-L1 抗体在晚期癌症患者中的安全性和活性。
N Engl J Med. 2012 Jun 28;366(26):2455-65. doi: 10.1056/NEJMoa1200694. Epub 2012 Jun 2.
8
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.抗 PD-1 抗体在癌症中的安全性、活性和免疫相关性。
N Engl J Med. 2012 Jun 28;366(26):2443-54. doi: 10.1056/NEJMoa1200690. Epub 2012 Jun 2.
9
Intratumoral interleukin-2/agonist CD40 antibody drives CD4+ -independent resolution of treated-tumors and CD4+ -dependent systemic and memory responses.肿瘤内白细胞介素 2/激动剂 CD40 抗体驱动经治疗肿瘤的 CD4+ 非依赖性消退和 CD4+ 依赖性全身和记忆应答。
Cancer Immunol Immunother. 2012 Apr;61(4):549-60. doi: 10.1007/s00262-011-1120-5. Epub 2011 Oct 15.
10
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans.CD40 激动剂可改变肿瘤基质，并在小鼠和人类中显示出对胰腺癌的疗效。
Science. 2011 Mar 25;331(6024):1612-6. doi: 10.1126/science.1198443.