Clinical Immunology Institute, The First Affiliated Hospital of Soochow University, Suzhou, China.
Oncol Res. 2013;20(9):383-92. doi: 10.3727/096504013X13657689382653.
Ovarian carcinomas are highly invasive, especially in the peritoneal cavity. SDF-1α and its receptor, CXCR4, play a crucial role in migration of cancer cells. Here, SDF-1α directed HO8910 cell migration, but not SKOV3 cells. After being educated to express CXCR4 in vivo or by treating with sCD40L, SDF-1α reexhibited the ability of directing SKOV3 cell migration, which could be antagonized by CXCR4-neutralizing antibody. Furthermore, concomitant expression of CXCR4/CD40 in ovarian carcinoma tissues had stronger correlation with pelvic metastasis than did each alone. It is suggest that SDF-1α acts through CXCR4 to induce ovarian cancer cell migration, which could be facilitated by CD40 activation. Simultaneously examining the expression of CXCR4 and CD40 will provide valuable diagnosis of pelvic metastasis for ovarian carcinomas.
卵巢癌具有高度侵袭性，尤其在腹腔内。SDF-1α及其受体 CXCR4 在癌细胞迁移中发挥着关键作用。在此，SDF-1α可诱导 HO8910 细胞迁移，但不能诱导 SKOV3 细胞迁移。体内表达 CXCR4 或用 sCD40L 处理后，SDF-1α 重新获得了诱导 SKOV3 细胞迁移的能力，这种迁移能力可被 CXCR4 中和抗体拮抗。此外，卵巢癌组织中 CXCR4/CD40 的共表达与盆腔转移的相关性比单独表达两者都要强。这表明 SDF-1α 通过 CXCR4 诱导卵巢癌细胞迁移，而 CD40 的激活可促进这种迁移。同时检测 CXCR4 和 CD40 的表达将为卵巢癌盆腔转移提供有价值的诊断。
