Institute of Rheumatology, and First Faculty of Medicine, Charles University, Na Slupi 4, 128 50, Prague 2, Czech Republic,
J Bone Miner Metab. 2013 Nov;31(6):606-12. doi: 10.1007/s00774-013-0494-1. Epub 2013 Aug 9.
Strontium ranelate is a medicine with evidenced effects on the risk of fractures. The heterogeneity of strontium distribution in bone, quality of bone mineral crystals in young bone packets on bone surfaces formed during strontium ranelate administration, and activation of the calcium sensing receptor may, at least partially, explain the beneficial effects of SrR on reducing the risk of fractures. In this review, the concept of the dual action of strontium ranelate is also discussed. However, sufficient evidence for the bone anabolic effect of SrR does not exist in humans. The knowledge of the mechanism of action of SrR is important not only for the explanation of the effects of SrR upon the skeleton, but also for the safety of treatment for other tissues.
雷奈酸锶是一种具有骨折风险降低作用的药物。雷奈酸锶在骨骼中的分布异质性、雷奈酸锶治疗期间在骨表面形成的年轻骨包中的骨矿物质晶体质量、钙敏感受体的激活，可能至少部分地解释了 SrR 降低骨折风险的有益作用。在本综述中，还讨论了雷奈酸锶的双重作用概念。然而，在人类中并没有足够的证据表明 SrR 具有骨合成代谢作用。了解 SrR 的作用机制不仅对于解释 SrR 对骨骼的作用很重要，而且对于治疗其他组织的安全性也很重要。
