Dept. of Pharmaceutical and Pharmacological Sciences, University of Padova, v. Marzolo 5, 35131 Padova, Italy.
Chem Commun (Camb). 2013 Sep 21;49(73):8057-9. doi: 10.1039/c3cc44382e. Epub 2013 Aug 7.
Transition metal complexes allow fine tuning of DNA binding affinity and selectivity. Here we report on the nucleic acid recognition properties of a phenanthroline-based ligand coordinated to Ni(2+) or Cu(2+). The resulting complexes clearly bind to telomeric G-quadruplexes at different sites according to the nature of the bound metal ion.
过渡金属配合物可以精细调节 DNA 的结合亲和力和选择性。在这里，我们报告了一种基于菲咯啉的配体与 Ni(2+)或 Cu(2+)配位的核酸识别特性。根据所结合的金属离子的性质，所得配合物可以在不同的位置上明确地与端粒 G-四链体结合。
