Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
Chem Commun (Camb). 2013 Sep 28;49(75):8338-40. doi: 10.1039/c3cc44866e.
A genetically encoded optogenetic system was constructed that activates mRNA translation in mammalian cells in response to light. Blue light induces the reconstitution of an RNA binding domain and a translation initiation domain, thereby activating target mRNA translation downstream of the binding sites.
构建了一种遗传编码的光遗传学系统，该系统可在哺乳动物细胞中响应光激活 mRNA 翻译。蓝光诱导 RNA 结合域和翻译起始域的重新组装，从而激活结合位点下游的靶 mRNA 翻译。
