光诱导哺乳动物细胞中靶 mRNA 翻译的激活。
Light-inducible activation of target mRNA translation in mammalian cells.
机构信息
Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
出版信息
Chem Commun (Camb). 2013 Sep 28;49(75):8338-40. doi: 10.1039/c3cc44866e.
PMID:23925486
Abstract
A genetically encoded optogenetic system was constructed that activates mRNA translation in mammalian cells in response to light. Blue light induces the reconstitution of an RNA binding domain and a translation initiation domain, thereby activating target mRNA translation downstream of the binding sites.
摘要
构建了一种遗传编码的光遗传学系统，该系统可在哺乳动物细胞中响应光激活 mRNA 翻译。蓝光诱导 RNA 结合域和翻译起始域的重新组装，从而激活结合位点下游的靶 mRNA 翻译。
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