通过路易斯酸催化给体-受体环丙烷与丙二腈的多米诺环开环-环化（DROC）反应，高效合成碳环烯胺腈。
An efficient synthetic route to carbocyclic enaminonitriles via Lewis acid catalysed domino-ring-opening-cyclisation (DROC) of donor-acceptor cyclopropanes with malononitrile.
机构信息
Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India.
出版信息
Chem Commun (Camb). 2013 Sep 25;49(74):8205-7. doi: 10.1039/c3cc44533j.
PMID:23925528
Abstract
A highly efficient strategy for the synthesis of functionalised carbocyclic enaminonitriles in excellent yields has been described. The reaction utilises Yb(OTf)3 catalysed C-C bond cleavage and two simultaneous C-C bond formations of donor-acceptor (DA)-cyclopropanes with malononitrile anions in a domino fashion.
摘要
已经描述了一种高效的合成功能化碳环烯胺腈的策略，产率非常高。该反应利用 Yb(OTf)3 催化的 C-C 键断裂和 DA-环丙烷与丙二腈阴离子的两个同时 C-C 键形成，以级联方式进行。
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