铁催化给体-受体环丙烷的多米诺反应：一种非对映选择性构建多官能化吡咯并喹唑啉的方法。

An iron-catalyzed domino reaction of donor-acceptor cyclopropanes: a diastereoselective approach towards diversely functionalized pyrrolo-quinazolines.

机构信息

Department of Chemistry, University of Calcutta 92, A. P. C. Road, Kolkata-700009, India.

出版信息

Org Biomol Chem. 2022 Feb 16;20(7):1415-1424. doi: 10.1039/d1ob02215f.

DOI:10.1039/d1ob02215f

Abstract

An expeditious synthetic route to access functionalized pyrrolo[2,1-]quinazoline scaffolds has been achieved domino ring opening cyclization (DROC) reactions of donor-acceptor (D-A) cyclopropanes and 2-amino(methyl)aniline derivatives. This novel iron catalyzed transformation is amenable to a wide range of substrates. Three new C-N bonds and two rings were sequentially constructed in this divergent one-pot process. The advantages of simple operation, high yields and general applicability make this procedure highly attractive and practical too.

摘要

已经实现了一种快速合成方法，可以获得功能化的吡咯并[2,1-]喹唑啉骨架，该方法是通过供体-受体（D-A）环丙烷和 2-氨基（甲基）苯胺衍生物的串联环开环（DROC）反应实现的。这种新型的铁催化转化适用于广泛的底物。在这个发散的一锅法过程中，连续构建了三个新的 C-N 键和两个环。该方法操作简单、产率高、适用性广，具有很高的吸引力和实用性。

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