Mutlu Serkan, Parlak Adem, Aydogan Umit, Aydogdu Aydogan, Soykut Bugra, Akay Cemal, Saglam Kenan, Taslipinar Abdullah
Department of Family Medicine, Gulhane School of Medicine, Ankara, Turkey.
Department of Family Medicine, Ağrı Military Hospital, Agri, Turkey.
Arch Pharm Res. 2021 Aug;44(8):1-9. doi: 10.1007/s12272-013-0227-y. Epub 2013 Aug 8.
The purpose of this present study is to investigate the levels of oxidative stress parameters in patients with subclinical hypothyroidism (SH) and the effects of levothyroxine (LT4) replacement therapy on these parameters and lipid profile. At the beginning of the study blood samples were collected from the patients in order to analyse oxidative stress parameters, lipid profile and biochemical markers. After replacement therapy with LT4, in the third month, same tests were performed again. At the baseline superoxide dismutase (SOD) levels were found to be higher in SH patients, compared to the euthyroid group. After LT4 therapy, statistically significant decreases in SOD and catalase levels and increase in HDL-C levels were noticed. LT4 treatment was found to have positive effects on oxidative stress indicators and HDL-C levels.
本研究的目的是调查亚临床甲状腺功能减退症（SH）患者的氧化应激参数水平，以及左甲状腺素（LT4）替代疗法对这些参数和血脂谱的影响。在研究开始时，采集患者的血样以分析氧化应激参数、血脂谱和生化标志物。在使用LT4进行替代治疗后，第三个月再次进行相同的检测。在基线时，发现SH患者的超氧化物歧化酶（SOD）水平高于甲状腺功能正常组。LT4治疗后，SOD和过氧化氢酶水平有统计学意义的下降，高密度脂蛋白胆固醇（HDL-C）水平升高。发现LT4治疗对氧化应激指标和HDL-C水平有积极影响。
