Department of Oncology, The Chinese PLA General Hospital, No. 28, Fuxing Street, Haidian District, Beijing 100853, People's Republic of China.
Med Oncol. 2013;30(3):683. doi: 10.1007/s12032-013-0683-8. Epub 2013 Aug 8.
The multidrug resistance 1 gene (MDR1) is an important candidate gene for influencing breast cancer susceptibility. This study aimed to evaluate the association between MDR1 genetic variants and breast cancer susceptibility. A total of 340 breast cancer patients and 348 cancer-free controls were enrolled in this study. The patients' general characteristics and related risk factors of breast cancer were collected by questionnaires. The c.4125A>C genetic variant was genotyped through created restriction site polymerase chain reaction method. Our data suggest that there are no significant differences in the allelic and genotypic frequencies between breast cancer patients and cancer-free controls. Moreover, the distribution of breast cancer patients' risk factors is not different among AA, AC, and CC genotypes. These preliminary results suggest that the c.4125A>C genetic variant is not significantly associated with breast cancer susceptibility.
多药耐药基因 1 （MDR1）是影响乳腺癌易感性的重要候选基因。本研究旨在评估 MDR1 基因变异与乳腺癌易感性之间的关系。本研究共纳入 340 例乳腺癌患者和 348 例无癌对照。通过问卷收集患者的一般特征和乳腺癌相关危险因素。通过创建的限制性内切酶聚合酶链反应方法对 c.4125A>C 基因变异进行基因分型。我们的数据表明，乳腺癌患者和无癌对照组之间等位基因和基因型频率没有显著差异。此外，AA、AC 和 CC 基因型的乳腺癌患者危险因素分布也没有差异。这些初步结果表明，c.4125A>C 基因变异与乳腺癌易感性无显著相关性。
