Division of Orthopaedic Surgery, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue MLC 2017, Cincinnati, OH 45229, USA.
J Bone Joint Surg Am. 2013 Aug 7;95(15):1345-50. doi: 10.2106/JBJS.L.00764.
Recent years have seen a trend toward more operative treatment of upper extremity fractures in children. The current study examines clinical research regarding pediatric upper extremity fracture treatment over the past twenty years in an attempt to identify research-based support for the increasingly aggressive treatment of these fractures.
Accepted abstracts on pediatric upper extremity fracture treatment presented at the Pediatric Orthopaedic Society of North America (POSNA) and the American Academy of Orthopaedic Surgeons (AAOS) annual meetings from 1993 through 2012 were reviewed. Abstracts were chosen rather than publications because of the larger number of abstracts that are available and because abstracts offer a more global representation of the research being performed by and presented to the members of these societies. The treatment recommendations of authors were classified as more aggressive, less aggressive, or neutral by two attending surgeons on the basis of which treatment was favored in comparative studies or how treatments in single-group studies compared with the standard of care at the time. Abstracts without treatment recommendations were excluded. Relationships between level of evidence, fracture location, and treatment recommendation were statistically evaluated with use of Spearman correlations and logistic regression analysis.
Overall, a higher proportion of studies gave less aggressive (47%, ninety of 190) or neutral (27%, fifty-one of 190) recommendations than more aggressive treatment recommendations (26%, forty-nine of 190). Only 24% of operative studies and 11% of nonoperative studies recommended more aggressive treatment (p = 0.001). Case series were more likely to recommend more aggressive treatments than comparative studies (30% versus 17%, p = 0.025). Also, studies with a smaller sample size were more likely to recommend more aggressive treatments (p = 0.006). The great majority of level-I and level-II (91%, ten of eleven), level-III (81%, thirty-nine of forty-eight), and level-IV (70%, ninety-two of 131) studies, however, provided either neutral or less-aggressive treatment recommendations.
The majority of research presented at POSNA and AAOS meetings over the past two decades fails to support the trend toward increasingly aggressive treatment of pediatric upper extremity fractures. This dichotomy between clinical research and the direction of clinical treatment must be explored in our efforts to provide evidence-based care of pediatric upper extremity fractures.
近年来,儿童上肢骨折的手术治疗呈上升趋势。本研究对过去 20 年中有关儿童上肢骨折治疗的临床研究进行了回顾,试图为这些骨折越来越积极的治疗提供循证支持。
对 1993 年至 2012 年期间在北美小儿矫形外科学会(POSNA)和美国矫形外科医师学会(AAOS)年会上提交的小儿上肢骨折治疗的已接受摘要进行了回顾。之所以选择摘要而不是出版物,是因为可获得的摘要数量更多,而且摘要更能全面反映这些学会成员所进行和提交的研究。两位主治医生根据比较研究中哪种治疗方法更受欢迎,或者单组研究中的治疗方法与当时的标准护理相比如何,将作者的治疗建议分为更积极、不那么积极或中性。没有治疗建议的摘要被排除在外。使用 Spearman 相关分析和逻辑回归分析对证据水平、骨折部位和治疗建议之间的关系进行了统计学评估。
总的来说,与更积极的治疗建议(47%,190 项中的 49 项)相比,更多的研究给出了不那么积极(27%,190 项中的 51 项)或中性(26%,190 项中的 49 项)的建议。只有 24%的手术研究和 11%的非手术研究建议更积极的治疗(p=0.001)。病例系列研究比比较研究更有可能建议更积极的治疗(30%比 17%,p=0.025)。此外,样本量较小的研究更有可能建议更积极的治疗(p=0.006)。然而,绝大多数的 1 级和 2 级(91%,11 项中的 10 项)、3 级(81%,48 项中的 39 项)和 4 级(70%,131 项中的 92 项)研究都提供了中性或不那么积极的治疗建议。
在过去 20 年中,POSNA 和 AAOS 会议上提交的大多数研究都没有支持儿童上肢骨折治疗越来越积极的趋势。在我们努力为儿童上肢骨折提供循证治疗的过程中,必须探讨这种临床研究与临床治疗方向之间的差异。