Yang Ying, Guo Su-xia, Yang Zhen-yu, Zhang Tao, Cao Hua-ming, Wang Ru-xing
Department of Cardiology, Affiliated People's Hospital of Nanjing Medical University in Wuxi and People's Hospital of Wuxi, Wuxi, Jiangsu 214023, P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2013 Aug;30(4):456-60. doi: 10.3760/cma.j.issn.1003-9406.2013.04.017.
To assess the association between 1019C/T polymorphism of Connexin 37 (CX37) gene and susceptibility to restenosis after percutaneous coronary intervention (PCI) in ethnic Han Chinese patients from Wuxi.
Five hundred and thirty-two patients with coronary artery disease (CAD) who had undergone PCI underwent coronary angiography (CAG) in 3 months, and were divided into in stent restenosis (ISR) group (n=67) and no instent restenosis (NISR) group (n=465). Five hundred and one healthy individuals have served as the control group. All cases were genotyped with DNA sequencing.
Compared with healthy controls, the frequency of CX37 C allele was higher in CAD patients (57.05% vs. 41.32%, P< 0.01). The frequency of C carries (CC+TC) was 79.32% in CAD patients, against 65.47% in healthy controls (P<0.01). The risk for CAD was significantly increased in carriers of C allele (CC+TC) compared with TT homozygotes (OR=2.03, 95% CI: 1.53-2.80). Stratified analysis has indicated a significant difference in the frequency of C allele carriers between both male and female CAD patients and healthy controls (79.63% vs. 72.45%, P=0.02; 78.00% vs. 51.50%, P< 0.01). For both genders, carriers of C allele had a higher risk for CAD compared with TT homozygotes (males: OR=1.48, 95% CI: 1.06-2.09; females: OR=3.34, 95% CI: 1.90-5.86). Compared with NISR group, the frequency of CX37 C allele and C carries (CC+TC) were significantly higher in ISR group (72.39% vs. 54.84%, P< 0.01; 89.55% vs. 77.85%, P=0.027). Compared with TT homozygotes, the risk for restenosis has significantly increased in carriers of C allele (CC+TC) (OR=2.44, 95% CI: 1.08-5.50). Stratified analysis also suggested that the frequency of C carriers was significantly higher in male ISR group compared with male NISR group (92. 86% vs. 77.66%, P=0.008). The risk for restenosis has increased by nearly four fold in carriers of C allele (CC+TC) compared with TT homozygotes (95% CI: 1.32-10.64). However, for female patients, no significant difference was detected in the ISR risk between carriers of CC+TC type and TT homozygotes (P=0.655).
The C allele of 1019C/T polymorphism in the CX37 gene is associated with susceptibility to CAD as well as restenosis after coronary stenting in male patients from Wuxi.
评估无锡地区汉族患者中连接蛋白37（CX37）基因1019C/T多态性与经皮冠状动脉介入治疗（PCI）后再狭窄易感性之间的关联。
532例接受PCI的冠心病（CAD）患者在3个月时接受冠状动脉造影（CAG），并分为支架内再狭窄（ISR）组（n = 67）和无支架内再狭窄（NISR）组（n = 465）。501名健康个体作为对照组。所有病例均采用DNA测序进行基因分型。
与健康对照组相比，CAD患者中CX37基因C等位基因频率更高（57.05%对41.32%，P < 0.01）。CAD患者中C携带者（CC + TC）的频率为79.32%，而健康对照组为65.47%（P < 0.01）。与TT纯合子相比，C等位基因携带者（CC + TC）患CAD的风险显著增加（OR = 2.03，95% CI：1.53 - 2.80）。分层分析表明，男性和女性CAD患者与健康对照组之间C等位基因携带者的频率存在显著差异（79.63%对72.45%，P = 0.02；78.00%对51.50%，P < 0.01）。对于两性，与TT纯合子相比，C等位基因携带者患CAD的风险更高（男性：OR = 1.48，95% CI：1.06 - 2.09；女性：OR = 3.34，95% CI：1.90 - 5.86）。与NISR组相比，ISR组中CX37基因C等位基因和C携带者（CC + TC）的频率显著更高（72.39%对54.84%，P < 0.01；89.55%对77.85%，P = 0.027）。与TT纯合子相比，C等位基因携带者（CC + TC）发生再狭窄的风险显著增加（OR = 2.44，95% CI：1.08 - 5.50）。分层分析还表明，男性ISR组中C携带者的频率显著高于男性NISR组（92.86%对
