Fan Lingzhong, Wang Jiaojian, Zhang Yu, Han Wei, Yu Chunshui, Jiang Tianzi
Brainnetome Center, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, PR China.
Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 625014, PR China.
Cereb Cortex. 2014 Dec;24(12):3365-78. doi: 10.1093/cercor/bht196. Epub 2013 Aug 7.
The temporal pole (TP) is an association cortex capable of multisensory integration and participates in various high-order cognitive functions. However, an accepted parcellation of the human TP and its connectivity patterns have not yet been well established. Here, we sought to present a scheme for the parcellation of human TP based on anatomical connectivity and to reveal its subregional connectivity patterns. Three distinct subregions with characteristic fiber pathways were identified, including the dorsal (TAr), the medial (TGm), and lateral (TGl) subregions, which are located ventrally. According to the connectivity patterns, a dorsal/ventral sensory segregation of auditory and visual processing and the medial TGm involved in the olfactory processing were observed. Combined with the complementary resting-state functional connectivity analysis, the connections of the TGm with the orbitofrontal cortex and other emotion-related areas, the TGl connections with the MPFC and major default mode network regions, and the TAr connections with the perisylvian language areas were observed. To the best of our knowledge, the present study represents the first attempt to parcel the human TP based on its anatomical connectivity features, which may help to improve our understanding of its connectional anatomy and to extend the available knowledge in TP-related clinical research.
颞极（TP）是一个能够进行多感官整合的联合皮质，参与各种高级认知功能。然而，人类颞极公认的分区及其连接模式尚未完全确立。在此，我们试图提出一种基于解剖连接的人类颞极分区方案，并揭示其亚区域连接模式。我们识别出三个具有特征性纤维通路的不同亚区域，包括位于腹侧的背侧（TAr）、内侧（TGm）和外侧（TGl）亚区域。根据连接模式，观察到听觉和视觉处理存在背侧/腹侧感觉分离，且内侧TGm参与嗅觉处理。结合互补的静息态功能连接分析，观察到TGm与眶额皮质及其他情绪相关区域的连接、TGl与内侧前额叶皮质及主要默认模式网络区域的连接，以及TAr与颞周语言区域的连接。据我们所知，本研究是首次基于其解剖连接特征对人类颞极进行分区的尝试，这可能有助于增进我们对其连接解剖的理解，并扩展颞极相关临床研究的现有知识。
