Hankins R W, Nagata K, Kato A, Ishihama A
Department of Molecular Genetics, National Institute of Genetics, Shizuoka, Japan.
Res Virol. 1990 May-Jun;141(3):305-14. doi: 10.1016/0923-2516(90)90002-z.
The mechanism by which influenza virus matrix (M1) protein inhibits viral RNA (vRNA) transcription was investigated. Evidence has been generated that M1 protein inhibits the steps of vRNA transcription initiation and reinitiation more effectively than that of RNA chain elongation. The vRNA-associated nucleocapsid protein (NP) appears to be critical for this inhibition, implying that M1 protein binds to the ribonucleoprotein complex (RNP) through NP.
研究了流感病毒基质（M1）蛋白抑制病毒RNA（vRNA）转录的机制。已有证据表明，M1蛋白对vRNA转录起始和重新起始步骤的抑制作用比对RNA链延伸步骤的抑制作用更有效。与vRNA相关的核衣壳蛋白（NP）似乎对这种抑制作用至关重要，这意味着M1蛋白通过NP与核糖核蛋白复合体（RNP）结合。
