Aoki Yuta, Inokuchi Ryota, Nakao Tomohiro, Yamasue Hidenori
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Psychiatry, Tokyo Metropolitan Health and Medical Treatment Corporation, Ebara Hospital, Ota-ku, Tokyo 145-0065, Japan, Department of Emergency and Critical Care Medicine, Department of Emergency and Critical Care Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan, and Japan Science and Technology Agency, CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Psychiatry, Tokyo Metropolitan Health and Medical Treatment Corporation, Ebara Hospital, Ota-ku, Tokyo 145-0065, Japan, Department of Emergency and Critical Care Medicine, Department of Emergency and Critical Care Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan, and Japan Science and Technology Agency, CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Psychiatry, Tokyo Metropolitan Health and Medical Treatment Corporation, Ebara Hospital, Ota-ku, Tokyo 145-0065, Japan, Department of Emergency and Critical Care Medicine, Department of Emergency and Critical Care Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan, and Japan Science and Technology Agency, CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan yuaoki-tky
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Psychiatry, Tokyo Metropolitan Health and Medical Treatment Corporation, Ebara Hospital, Ota-ku, Tokyo 145-0065, Japan, Department of Emergency and Critical Care Medicine, Department of Emergency and Critical Care Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan, and Japan Science and Technology Agency, CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, JapanDepartment of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Psychiatry, Tokyo Metropolitan Health and Medical Treatment Corporation, Ebara Hospital, Ota-ku, Tokyo 145-0065, Japan, Department of Emergency and Critical Care Medicine, Department of Emergency and Critical Care Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan, Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan, and Japan Science and Technology Agency, CREST, 5 Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan.
Soc Cogn Affect Neurosci. 2014 Aug;9(8):1223-31. doi: 10.1093/scan/nst104. Epub 2013 Aug 6.
Individuals with antisocial behavior place a great physical and economic burden on society. Deficits in emotional processing have been recognized as a fundamental cause of antisocial behavior. Emerging evidence also highlights a significant contribution of attention allocation deficits to such behavior. A comprehensive literature search identified 12 studies that were eligible for inclusion in the meta-analysis, which compared 291 individuals with antisocial problems and 247 controls. Signed Differential Mapping revealed that compared with controls, gray matter volume (GMV) in subjects with antisocial behavior was reduced in the right lentiform nucleus (P < 0.0001), left insula (P = 0.0002) and left frontopolar cortex (FPC) (P = 0.0006), and was increased in the right fusiform gyrus (P < 0.0001), right inferior parietal lobule (P = 0.0003), right superior parietal lobule (P = 0.0004), right cingulate gyrus (P = 0.0004) and the right postcentral gyrus (P = 0.0004). Given the well-known contributions of limbic and paralimbic areas to emotional processing, the observed reductions in GMV in these regions might represent neural correlates of disturbance in emotional processing underlying antisocial behavior. Previous studies have suggested an FPC role in attention allocation during emotional processing. Therefore, GMV deviations in this area may constitute a neural basis of deficits in attention allocation linked with antisocial behavior.
具有反社会行为的个体给社会带来了巨大的身体和经济负担。情绪加工缺陷已被认为是反社会行为的一个根本原因。新出现的证据还突出了注意力分配缺陷对这种行为的重大影响。一项全面的文献检索确定了12项符合纳入荟萃分析条件的研究，这些研究比较了291名有反社会问题的个体和247名对照组。符号差异映射显示，与对照组相比，反社会行为个体的右侧豆状核（P < 0.0001）、左侧岛叶（P = 0.0002）和左侧额极皮质（FPC）（P = 0.0006）的灰质体积（GMV）减少，而右侧梭状回（P < 0.0001）、右侧顶下小叶（P = 0.0003）、右侧顶上小叶（P = 0.0004）、右侧扣带回（P = 0.0004）和右侧中央后回（P = 0.0004）的GMV增加。鉴于边缘和边缘旁区域对情绪加工的众所周知的作用，这些区域观察到的GMV减少可能代表了反社会行为背后情绪加工障碍的神经关联。先前的研究表明FPC在情绪加工过程中的注意力分配中起作用。因此，该区域的GMV偏差可能构成与反社会行为相关的注意力分配缺陷的神经基础。
