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非肥胖日本儿童青春期的胰岛素抵抗

Insulin Resistance during Puberty in Non-obese Japanese Children.

作者信息

Morimoto Shigeo, Urakami Tatsuhiko

机构信息

Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.

出版信息

Clin Pediatr Endocrinol. 2011 Jan;20(1):1-6. doi: 10.1297/cpe.20.1. Epub 2011 Mar 26.

DOI:10.1297/cpe.20.1
PMID:23926387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3687630/
Abstract

We examined whether non-obese Japanese children without diabetes exhibited insulin resistance during puberty. The study subjects were 201 Japanese school students, consisting 95 males and 106 females, aged 11.5 ± 2.6 yr. None of the subjects were obese, with the mean percent of overweight being 0.7 ± 10.5%, or had diabetes at the time of the study. Overnight fasting plasma values of insulin (FIRI) and HOMA-R were measured, with concomitant measurement of the plasma glucose (FPG) levels. The mean FPG, FIRI and HOMA-R values were 89.6 ± 7.3 (70-109) mg/dl, 9.0 ± 3.6 (1.7-24.4) µU/ml and 2.0 ± 0.9 (0.3-5.2), respectively. The mean FIRI value was significantly higher in females than in males (8.3 ± 3.4 vs. 9.6 ± 3.7 µU/ml, p=0.0060). The FIRI and HOMA-R values of the pubertal students were significantly higher compared with those of the prepubertal students (FIRI, 10.0 ± 3.4 vs. 6.5 ± 2.8 µU/ml; HOMA-R, 2.3 ± 0.8 vs. 1.4 ± 0.7; p<0.0001 for both). Similar trends were observed between the two genders. The mean FIRI levels and HOMA-R values were positively correlated with age (FIRI, r=0.280, p<0.0001; HOMA-R, r=0.300, p<0.0001). In conclusion, we demonstrated that the FIRI and HOMA-R values were significantly associated with pubertal development in non-obese Japanese children without diabetes, consistent with the results of studies in white and black children.

摘要

我们研究了无糖尿病的非肥胖日本儿童在青春期是否存在胰岛素抵抗。研究对象为201名日本在校学生，其中男性95名，女性106名，年龄为11.5±2.6岁。所有研究对象均不肥胖，超重平均百分比为0.7±10.5%，且在研究时均无糖尿病。测量了过夜空腹胰岛素血浆值（FIRI）和HOMA-R，并同时测量了血浆葡萄糖（FPG）水平。FPG、FIRI和HOMA-R的平均值分别为89.6±7.3（70 - 109）mg/dl、9.0±3.6（1.7 - 24.4）µU/ml和2.0±0.9（0.3 - 5.2）。女性的平均FIRI值显著高于男性（8.3±3.4 vs. 9.6±3.7 µU/ml，p = 0.0060）。青春期学生的FIRI和HOMA-R值显著高于青春期前学生（FIRI，10.0±3.4 vs. 6.5±2.8 µU/ml；HOMA-R，2.3±0.8 vs. 1.4±0.7；两者p均<0.0001）。在两种性别之间观察到类似趋势。平均FIRI水平和HOMA-R值与年龄呈正相关（FIRI，r = 0.280，p<0.0001；HOMA-R，r = 0.300，p<0.0001）。总之，我们证明了FIRI和HOMA-R值与无糖尿病的非肥胖日本儿童的青春期发育显著相关，这与白种人和黑种人儿童的研究结果一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/3687630/fa7c749965dc/cpe-20-001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/3687630/4cffa920cb33/cpe-20-001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/3687630/ae55d64663ab/cpe-20-001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/3687630/363d6d471039/cpe-20-001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/3687630/fa7c749965dc/cpe-20-001-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/3687630/4cffa920cb33/cpe-20-001-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/3687630/ae55d64663ab/cpe-20-001-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/3687630/363d6d471039/cpe-20-001-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f26/3687630/fa7c749965dc/cpe-20-001-g004.jpg

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