Abe Yuki, Kikuchi Toru, Nagasaki Keisuke, Hiura Makoto, Tanaka Yukie, Ogawa Yohei, Uchiyama Makoto
Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan ; Department of Pediatrics, Niigata City General Hospital, Niigata, Japan.
Clin Pediatr Endocrinol. 2011 Jan;20(1):13-20. doi: 10.1297/cpe.20.13. Epub 2011 Mar 26.
The aim of this study was to clarify the relationship between preheparin lipoprotein lipase (LPL) and derangements of metabolic status in obese Japanese children. We examined 102 obese children (55 boys and 47 girls; mean age 10.9 yr). Anthropometry, blood pressure and levels of liver transaminases, serum lipids and lipoproteins, uric acid, fasting blood glucose (FBG), serum insulin, LPL, leptin and adiponectin were measured. The subjects were divided into the metabolic syndrome (MS) and non-MS groups. The levels of LPL were compared between these groups. Statistical analysis showed that the LPL levels were significantly lower in the MS group compared with the non-MS group, with the levels decreasing progressively as the number of MS components increased. We conclude that LPL levels decrease also in obese Japanese children with a deteriorated metabolic status in the same way as in adults.
本研究的目的是阐明肝素前脂蛋白脂肪酶（LPL）与肥胖日本儿童代谢状态紊乱之间的关系。我们对102名肥胖儿童（55名男孩和47名女孩；平均年龄10.9岁）进行了检查。测量了人体测量学指标、血压、肝转氨酶水平、血脂和脂蛋白、尿酸、空腹血糖（FBG）、血清胰岛素、LPL、瘦素和脂联素。将受试者分为代谢综合征（MS）组和非MS组。比较了两组之间的LPL水平。统计分析表明，与非MS组相比，MS组的LPL水平显著降低，且随着MS组分数量的增加，LPL水平逐渐下降。我们得出结论，与成年人一样，代谢状态恶化的肥胖日本儿童的LPL水平也会降低。
