Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Japan.
J Atheroscler Thromb. 2009;16(6):902-9. doi: 10.5551/jat.1933. Epub 2009 Dec 22.
The aim of this study was to evaluate the usefulness of glutamate pyruvate transaminase (GPT) levels in the diagnosis of metabolic syndrome (MS) in obese Japanese children.
We examined 193 obese boys (mean age: 12.1 yrs; mean percent overweight [POW]: 53.9%) and 37 obese girls (mean age: 11.4 yrs; mean POW: 57.2%). Anthropometric measurements, blood pressure and levels of liver transaminases, serum lipids and lipoproteins, fasting blood glucose (FBG), serum insulin and adiponectin were measured. The subjects were divided into either an MS or a non-MS group according to the MS definition criteria for Japanese children.
The level of GPT was significantly higher in the MS group in both genders. Correlation analysis revealed positive correlations between GPT and waist circumference, blood pressure, maximum preperitoneal fat thickness, serum insulin and homeostasis model assessment-insulin resistance (HOMA-R), but no correlation between GPT and FBG. ANOVA showed a significant difference in GPT levels between MS and non-MS subgroups, whereas there was no difference in FBG between the two groups. Receiver operating characteristic curves demonstrated that GPT was clearly superior to FBG as a diagnostic marker of MS.
We conclude that an elevation in GPT in obese children most likely reflects insulin resistance and that GPT is superior to FBG as a marker of MS.
本研究旨在评估谷氨酸丙酮酸转氨酶（GPT）水平在诊断日本肥胖儿童代谢综合征（MS）中的作用。
我们检查了 193 名肥胖男孩（平均年龄：12.1 岁；平均超重百分比[POW]：53.9%）和 37 名肥胖女孩（平均年龄：11.4 岁；平均 POW：57.2%）。测量了人体测量学指标、血压以及肝转氨酶、血脂和脂蛋白、空腹血糖（FBG）、血清胰岛素和脂联素水平。根据日本儿童 MS 定义标准，将受试者分为 MS 组或非 MS 组。
男女两性中，MS 组的 GPT 水平均显著升高。相关性分析显示，GPT 与腰围、血压、最大腹膜前脂肪厚度、血清胰岛素和稳态模型评估-胰岛素抵抗指数（HOMA-R）呈正相关，而与 FBG 无相关性。方差分析显示，MS 组和非 MS 组之间 GPT 水平存在显著差异，而两组之间 FBG 水平无差异。受试者工作特征曲线表明，GPT 作为 MS 的诊断标志物明显优于 FBG。
我们得出结论，肥胖儿童中 GPT 的升高很可能反映了胰岛素抵抗，并且 GPT 作为 MS 的标志物优于 FBG。
