Takeuchi Takako, Kamasaki Hotaka, Hotsubo Tomoyuki, Tsutsumi Hiroyuki
Department of Pediatrics, Sapporo Medical University, School of Medicine, Sapporo, Japan.
Clin Pediatr Endocrinol. 2011 Jul;20(3):51-5. doi: 10.1297/cpe.20.51. Epub 2011 Oct 7.
We investigated thyroid function and urinary iodine concentration (UIC) in seven patients with severe motor intellectual disabilities. All seven received total enteral nutrition (TEN) for more than three years with a daily iodine intake of less than 20 µg. They were diagnosed as hypothyroidism due to iodine deficiency (HID) because of high TSH levels (7.6-82.3 µIU/ml), lower free T4 (FT4 0.4-1.5 ng/dl), negative anti-thyroid antibodies (anti-thyroglobulin antibody, anti-thyroidal peroxidase antibody) and extremely low UIC (<25-58 µg/l) levels. We gave them 1-2 g powdered kelp (200-400 µg as iodine) once a day, which restored their thyroid function and normalized their UICs. We proposed that daily powdered kelp would be effective and safe to treat HID in patient receiving long term TEN.
我们对7例重度运动智力残疾患者的甲状腺功能和尿碘浓度（UIC）进行了研究。所有7例患者均接受全肠内营养（TEN）超过三年，每日碘摄入量低于20μg。由于促甲状腺激素（TSH）水平较高（7.6 - 82.3μIU/ml）、游离甲状腺素（FT4）较低（0.4 - 1.5ng/dl）、抗甲状腺抗体（抗甲状腺球蛋白抗体、抗甲状腺过氧化物酶抗体）阴性以及UIC水平极低（<25 - 58μg/l），他们被诊断为碘缺乏性甲状腺功能减退症（HID）。我们每天给他们服用1 - 2克海带粉（含碘200 - 400μg），这恢复了他们的甲状腺功能并使UIC正常化。我们提出，对于接受长期TEN的患者，每日服用海带粉对治疗HID是有效且安全的。
