Demir Mehmet, Oba Ersin, Can Efe, Kara Orhan, Cinar Sonmez
Sisli Etfal Training and Research Hospital, Department of Ophthalmology, Istanbul, Turkey.
Ophthalmol Eye Dis. 2013 Jul 15;5:11-5. doi: 10.4137/OED.S12352. Print 2013.
We evaluated the effect of intravitreal bevacizumab (IVB) injection before pars plana vitrectomy (PPV) on intravitreal hemorrhage (VH) during and after vitrectomy for postoperative the first day and the first month in pseudophakic patients with proliferative diabetic retinopathy (PDR). This retrospective study was performed on 44 eyes of 44 patients who underwent vitrectomy for PDR. Patients were divided into PPV (n = 22 eyes) and PPV + IVB (n = 22 eyes) groups. Injection of bevacizumab (1.25 mg/0.05 mL) was performed 3 days before vitrectomy. Outcomes of visual acuity as well as intraoperative and postoperative VH were compared between the two groups. One month after surgery, visual acuity improved in PPV and PPV + IVB groups (P = 0.005, P = 0.006), respectively. There was no difference between the two groups in best corrected visual acuity at baseline and after vitrectomy (P = 0.71). Intraoperative bleeding into the vitreous was recorded in 14 (63.6%) cases in the PPV group and in 7 (31.8%) cases in the PPV + IVB group. The first month, intravitreal hemorrhage was recorded in six patients in the PPV group and in two patients in the PPV + IVB group (P = 0.03). The mean pre-postoperative central macular thickness was similar in both groups. Intravitreal injection of IVB before vitrectomy decreased the rate of VH at the time of surgery and at the first postoperative month in patients with PDR.
我们评估了在玻璃体切割术前玻璃体内注射贝伐单抗（IVB）对增殖性糖尿病视网膜病变（PDR）的人工晶状体眼患者玻璃体切割术中及术后第一天和第一个月玻璃体出血（VH）的影响。这项回顾性研究对44例因PDR接受玻璃体切除术的患者的44只眼进行。患者被分为单纯玻璃体切割术（PPV，n = 22只眼）组和玻璃体切割术联合IVB（PPV + IVB，n = 22只眼）组。在玻璃体切割术前3天注射贝伐单抗（1.25 mg/0.05 mL）。比较两组的视力结果以及术中及术后的VH情况。术后1个月，PPV组和PPV + IVB组的视力分别有所改善（P = 0.005，P = 0.006）。两组在基线时和玻璃体切割术后的最佳矫正视力无差异（P = 0.71）。PPV组有14例（63.6%）术中玻璃体出血，PPV + IVB组有7例（31.8%）。在第一个月，PPV组有6例患者发生玻璃体出血，PPV + IVB组有2例患者发生（P = 0.03）。两组术前术后黄斑中心厚度均值相似。玻璃体切割术前玻璃体内注射IVB可降低PDR患者手术时及术后第一个月的VH发生率。
