玻璃体切割术前玻璃体腔内注射贝伐单抗对增殖性糖尿病视网膜病变的影响。
Effect of intravitreal bevacizumab injection before vitrectomy on proliferative diabetic retinopathy.
作者信息
Li Cai-Rui, Sun Shu-Guang, Hong Wei
机构信息
Department of Ophthalmology, Hospital of Dali University, Dali 671000, Yunnan Province, China.
出版信息
Int J Ophthalmol. 2010;3(3):261-3. doi: 10.3980/j.issn.2222-3959.2010.03.19. Epub 2010 Sep 18.
AIM
To evaluate the effect of intravitreal bevacizumab (IVB) injection 1 week before pars plana vitrectomy (PPV) in proliferative diabetic retinopathy (PDR) patients.
METHODS
A retrospective research was done on 46 PDR patients who were divided into PPV group (n=28) and IVB group (n=18, PPV with preoperative IVB). Bevacizumab was injected 1 week before PPV. Main outcome measures were visual acuity, incidence of iatrogenic retinal breaks, intraoperative and postoperative bleeding.
RESULTS
At 1 month after surgery, visual acuity in PPV (82.1%) and IVB group (88.9%) improved significantly (P<0.01) and the difference between the two groups was not significant (P>0.05). Iatrogenic retinal breaks were reported in 18 cases (64.3%) in PPV group and 4 cases (22.2%) in IVB group (P<0.05). Intraoperative bleeding was encountered in all cases in PPV group and 7 cases (39%) in IVB group (P<0.01). Postoperative bleeding was reported in 9 cases (32.1%) in PPV group and none in IVB group (P<0.01).
CONCLUSION
IVB injection before PPV is helpful in reducing iatrogenic retinal breaks, intraoperative and postoperative bleeding in PDR patients.
目的
评估在增生性糖尿病视网膜病变（PDR）患者中，玻璃体腔注射贝伐单抗（IVB）1周后行玻璃体切割术（PPV）的效果。
方法
对46例PDR患者进行回顾性研究，将其分为PPV组（n = 28）和IVB组（n = 18，术前IVB联合PPV）。在PPV前1周注射贝伐单抗。主要观察指标为视力、医源性视网膜裂孔发生率、术中及术后出血情况。
结果
术后1个月，PPV组（82.1%）和IVB组（88.9%）的视力均显著提高（P<0.01），两组间差异无统计学意义（P>0.05）。PPV组有18例（64.3%）发生医源性视网膜裂孔，IVB组有4例（22.2%）发生（P<0.05）。PPV组所有病例均出现术中出血，IVB组有7例（39%）出现术中出血（P<0.01）。PPV组有9例（32.1%）出现术后出血，IVB组无术后出血病例（P<0.01）。
结论
PPV前注射IVB有助于减少PDR患者的医源性视网膜裂孔、术中及术后出血。
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