Li Cai-Rui, Sun Shu-Guang, Hong Wei
Department of Ophthalmology, Hospital of Dali University, Dali 671000, Yunnan Province, China.
Int J Ophthalmol. 2010;3(3):261-3. doi: 10.3980/j.issn.2222-3959.2010.03.19. Epub 2010 Sep 18.
To evaluate the effect of intravitreal bevacizumab (IVB) injection 1 week before pars plana vitrectomy (PPV) in proliferative diabetic retinopathy (PDR) patients.
A retrospective research was done on 46 PDR patients who were divided into PPV group (n=28) and IVB group (n=18, PPV with preoperative IVB). Bevacizumab was injected 1 week before PPV. Main outcome measures were visual acuity, incidence of iatrogenic retinal breaks, intraoperative and postoperative bleeding.
At 1 month after surgery, visual acuity in PPV (82.1%) and IVB group (88.9%) improved significantly (P<0.01) and the difference between the two groups was not significant (P>0.05). Iatrogenic retinal breaks were reported in 18 cases (64.3%) in PPV group and 4 cases (22.2%) in IVB group (P<0.05). Intraoperative bleeding was encountered in all cases in PPV group and 7 cases (39%) in IVB group (P<0.01). Postoperative bleeding was reported in 9 cases (32.1%) in PPV group and none in IVB group (P<0.01).
IVB injection before PPV is helpful in reducing iatrogenic retinal breaks, intraoperative and postoperative bleeding in PDR patients.
评估在增生性糖尿病视网膜病变（PDR）患者中，玻璃体腔注射贝伐单抗（IVB）1周后行玻璃体切割术（PPV）的效果。
对46例PDR患者进行回顾性研究，将其分为PPV组（n = 28）和IVB组（n = 18，术前IVB联合PPV）。在PPV前1周注射贝伐单抗。主要观察指标为视力、医源性视网膜裂孔发生率、术中及术后出血情况。
术后1个月，PPV组（82.1%）和IVB组（88.9%）的视力均显著提高（P<0.01），两组间差异无统计学意义（P>0.05）。PPV组有18例（64.3%）发生医源性视网膜裂孔，IVB组有4例（22.2%）发生（P<0.05）。PPV组所有病例均出现术中出血，IVB组有7例（39%）出现术中出血（P<0.01）。PPV组有9例（32.1%）出现术后出血，IVB组无术后出血病例（P<0.01）。
PPV前注射IVB有助于减少PDR患者的医源性视网膜裂孔、术中及术后出血。
