大分子催乳素；临床实践中高催乳素血症误诊的常见原因。
Macroprolactin; a frequent cause of misdiagnosed hyperprolactinemia in clinical practice.
作者信息
Richa Vaishya, Rahul Gupta, Sarika Arora
机构信息
Guru Nanak Eye Center, New Delhi, India.
出版信息
J Reprod Infertil. 2010 Oct;11(3):161-7.
INTRODUCTION
Macroprolactin is a significant cause of misdiagnosis, unnecessary investigation, and inappropriate treatment in patients with hyperprolactinemia. Its frequency has not been clearly established due to technical difficulties in identifying it. Most laboratories and clinicians are unaware of macroprolactin interferences in prolactin assays.
MATERIALS AND METHODS
A comprehensive literature search was conducted on the websites of the National Library of Medicine (http://www.ncbl.nlm.nih.gov) and PubMed Central, the US National Library of Medicine's digital archive of life sciences literature (http://www.pubmedcentral.nih.gov/). The data were also looked for in relevant books and journal.
RESULTS
Macroprolactin is a non-bioactive prolactin isoform usually composed of a prolactin monomer and an IgG molecule having a prolonged clearance rate similar to that of immunoglobulins. This isoform is clinically non-reactive but it interferes with immunological assays used for the detection of prolactin.
CONCLUSION
There is a need to understand and explore the recent progress in the diagnosis and pathophysiology of macroprolactinemia for improving patient care.
引言
巨泌乳素血症是高泌乳素血症患者误诊、不必要检查及不恰当治疗的重要原因。由于鉴定存在技术困难，其发生率尚未明确确定。大多数实验室和临床医生并不知晓巨泌乳素对泌乳素检测的干扰。
材料与方法
在国立医学图书馆网站（http://www.ncbl.nlm.nih.gov）和美国国立医学图书馆生命科学文献数字存档库PubMed Central（http://www.pubmedcentral.nih.gov/）上进行了全面的文献检索。还在相关书籍和期刊中查找了数据。
结果
巨泌乳素是一种无生物活性的泌乳素异构体，通常由一个泌乳素单体和一个免疫球蛋白G分子组成，其清除率延长，与免疫球蛋白相似。这种异构体在临床上无反应，但会干扰用于检测泌乳素的免疫测定。
结论
有必要了解和探索巨泌乳素血症诊断和病理生理学方面的最新进展，以改善患者护理。
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