Del Río Juan Pablo, Tapia Valeska, Soto Hugo, Vigil Pilar
Departamento de Psiquiatría y Salud Mental de la Infancia y de la Adolescencia, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Millennium Nucleus to Improve the Mental Health of Adolescents and Youths Imhay, Santiago, Chile.
Front Psychol. 2024 Aug 21;15:1433437. doi: 10.3389/fpsyg.2024.1433437. eCollection 2024.
Hormones produced by the hypothalamic-pituitary-adrenal-gonadal (HPAG) axis are crucial for modulating central nervous system (CNS) function and development throughout a person's life. Disruptions in HPAG function can impact psychological development, particularly during adolescence-a period marked by psychological growth and the maturation of the HPAG axis. An early indicator of HPAG alterations is ovulatory dysfunction (OD), a common condition among adolescents.
This study explored the associations between neuroactive hormones and personal growth in adolescents with OD. Female participants aged 12-25 years with OD were recruited, and assessments were conducted to profile their basic hormonal levels and various dimensions of individual development, including self-concept clarity, sense of coherence, self-esteem, perfectionism, self-control, and mood states.
Adolescents with OD ( = 117) had lower self-concept clarity and self-esteem compared to reference data. A significant portion of the sample displayed elevated levels of tension (71.25%), confusion (62.5%), fatigue (58.22%), and depression (52.6%). Self-esteem scores were negatively correlated with DHEAS ( = -0.224; = 0.026) and glucose ( = -0.249; = 0.010). Higher levels of free testosterone were associated with increased depression scores (coef = 0.2398; = 0.002), whereas higher estradiol levels were linked to lower aggressiveness scores (coef = -0.0648; = 0.001).
These findings indicate that hormonal imbalances in adolescents with OD could affect personal growth. Further research is needed to establish causal relationships between the variables considered.
下丘脑 - 垂体 - 肾上腺 - 性腺（HPAG）轴产生的激素对于调节人一生中的中枢神经系统（CNS）功能和发育至关重要。HPAG功能紊乱会影响心理发展，尤其是在青春期，这是一个以心理成长和HPAG轴成熟为特征的时期。HPAG改变的一个早期指标是排卵功能障碍（OD），这在青少年中是一种常见情况。
本研究探讨了患有OD的青少年中神经活性激素与个人成长之间的关联。招募了年龄在12 - 25岁之间患有OD的女性参与者，并进行评估以描绘她们的基本激素水平以及个人发展的各个维度，包括自我概念清晰度、连贯感、自尊、完美主义、自我控制和情绪状态。
与参考数据相比，患有OD的青少年（n = 117）的自我概念清晰度和自尊较低。很大一部分样本表现出紧张水平升高（71.25%）、困惑（62.5%）、疲劳（58.22%）和抑郁（52.6%）。自尊得分与硫酸脱氢表雄酮（r = -0.224；p = 0.026）和葡萄糖（r = -0.249；p = 0.010）呈负相关。游离睾酮水平较高与抑郁得分增加相关（系数 = 0.2398；p = 0.002），而雌二醇水平较高与攻击性得分较低相关（系数 = -0.0648；p = 0.001）。
这些发现表明，患有OD的青少年激素失衡可能会影响个人成长。需要进一步研究以确定所考虑变量之间的因果关系。
